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EnglishThe antiproliferative and differentiation potential of anthocyanin-rich strawberry fruit crude extracts (SE) were investigated on B16-F10 murine melanoma cells. Treatment of melanoma cells with SE produced a remarkable reduction of cell proliferation, paralleled with both the lowering of the intracellular levels of polyamine, and the enhancement of tissue transglutaminase (TG2, EC 2.3.2.13) activity (used as a differentiation marker). To gain further insight into profiling altered protein expression as a potential biomarker of the SE action on melanoma cells, analysis of the proteomic profile was performed on the treated B16-F10 cells, compared to the control. Following SE treatment, 30 proteins resulted up-regulated, and 87 proteins were down-regulated. In particular proteins overexpressed in cancer cells, involved in tumor progression and metabolism, were down-regulated. The possibility that SE may affect the Warburg effect in B16-F10 melanoma cells is discussed.
Forni, C., Braglia, R., Mulinacci, N., Urbani, A., Ronci, M., Gismondi, A., et al. (2014). Antineoplastic activity of strawberry (Fragaria × ananassa Duch.) crude extracts on B16-F10 melanoma cells. MOLECULAR BIOSYSTEMS, 10(6), 1255-1263.
| Tipologia: | Articolo su rivista | |
| Citazione: | Forni, C., Braglia, R., Mulinacci, N., Urbani, A., Ronci, M., Gismondi, A., et al. (2014). Antineoplastic activity of strawberry (Fragaria × ananassa Duch.) crude extracts on B16-F10 melanoma cells. MOLECULAR BIOSYSTEMS, 10(6), 1255-1263. | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore BIO/01 | |
| Revisione (peer review): | Esperti anonimi | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/c3mb70316a | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 2014 | |
| Titolo: | Antineoplastic activity of strawberry (Fragaria × ananassa Duch.) crude extracts on B16-F10 melanoma cells | |
| Autori: | ||
| Autori: | Forni, C; Braglia, R; Mulinacci, N; Urbani, A; Ronci, M; Gismondi, A; Tabolacci, C; Provenzano, B; Lentini, A; Beninati, S | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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