To evaluate whether etravirine (TMC125) might be effective in patients failing therapy with current nonnucleoside reverse transcriptase inhibitors (NNRTIs), we analysed the prevalence of TMC125 mutations and the possible determinants of genotypic resistance to this drug among sequences reported to a large database in Italy [Antiretroviral Resistance Cohort Analysis (ARCA)].

Di Vincenzo, P., Rusconi, S., Adorni, F., Vitiello, P., Maggiolo, F., Francisci, D., et al. (2010). Prevalence of mutations and determinants of genotypic resistance to etravirine (TMC125) in a large Italian resistance database (ARCA). HIV MEDICINE, 11(8), 530-534 [10.1111/j.1468-1293.2009.00819.x].

Prevalence of mutations and determinants of genotypic resistance to etravirine (TMC125) in a large Italian resistance database (ARCA)

PERNO, CARLO FEDERICO;
2010-09-01

Abstract

To evaluate whether etravirine (TMC125) might be effective in patients failing therapy with current nonnucleoside reverse transcriptase inhibitors (NNRTIs), we analysed the prevalence of TMC125 mutations and the possible determinants of genotypic resistance to this drug among sequences reported to a large database in Italy [Antiretroviral Resistance Cohort Analysis (ARCA)].
set-2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Drug resistance, viral; male; retrospective studies; multivariate analysis; mutation; HIV infections; female; HIV reverse transcriptase; Italy; genotype; treatment failure; humans; prevalence; HIV-1; pyridazines; adult; anti-retroviral agents
Di Vincenzo, P., Rusconi, S., Adorni, F., Vitiello, P., Maggiolo, F., Francisci, D., et al. (2010). Prevalence of mutations and determinants of genotypic resistance to etravirine (TMC125) in a large Italian resistance database (ARCA). HIV MEDICINE, 11(8), 530-534 [10.1111/j.1468-1293.2009.00819.x].
Di Vincenzo, P; Rusconi, S; Adorni, F; Vitiello, P; Maggiolo, F; Francisci, D; Di Biagio, A; Monno, L; Antinori, A; Boeri, E; Punzi, G; Perno, Cf; Callegaro, A; Bruzzone, B; Zazzi, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/18322
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