Intracellular HCV-RNA reduction is a proposed mechanism of action of direct-acting antivirals (DAAs), alternative to hepatocytes elimination by pegylated-interferon plus ribavirin (PR). We modeled ALT and HCV-RNA kinetics in cirrhotic patients treated with currently-used all-DAA combinations to evaluate their mode of action and cytotoxicity compared with telaprevir (TVR)+PR.

Cento, V., Nguyen, T., Di Carlo, D., Biliotti, E., Gianserra, L., Lenci, I., et al. (2017). Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens. PLOS ONE, 12(5), e0177352 [10.1371/journal.pone.0177352].

Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens

CENTO, VALERIA;LENCI, ILARIA;DI PAOLO, DANIELE;TETI, ELISABETTA;DI MAIO, VELIA CHIARA;SARMATI, LOREDANA;BERNARDINI, SERGIO;ANDREONI, MASSIMO;ANGELICO, MARIO;PERNO, CARLO FEDERICO;CECCHERINI SILBERSTEIN, FRANCESCA
2017

Abstract

Intracellular HCV-RNA reduction is a proposed mechanism of action of direct-acting antivirals (DAAs), alternative to hepatocytes elimination by pegylated-interferon plus ribavirin (PR). We modeled ALT and HCV-RNA kinetics in cirrhotic patients treated with currently-used all-DAA combinations to evaluate their mode of action and cytotoxicity compared with telaprevir (TVR)+PR.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/17 - Malattie Infettive
English
Con Impact Factor ISI
Cento, V., Nguyen, T., Di Carlo, D., Biliotti, E., Gianserra, L., Lenci, I., et al. (2017). Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens. PLOS ONE, 12(5), e0177352 [10.1371/journal.pone.0177352].
Cento, V; Nguyen, T; Di Carlo, D; Biliotti, E; Gianserra, L; Lenci, I; DI PAOLO, D; Calvaruso, V; Teti, E; Cerrone, M; Romagnoli, D; Melis, M; Danieli, E; Menzaghi, B; Polilli, E; Siciliano, M; Nicolini, L; Di Biagio, A; Magni, C; Bolis, M; Antonucci, F; DI MAIO, Vc; Alfieri, R; Sarmati, L; Casalino, P; Bernardini, S; Micheli, V; Rizzardini, G; Parruti, G; Quirino, T; Puoti, M; Babudieri, S; D'Arminio Monforte, A; Andreoni, M; Craxì, A; Angelico, M; Pasquazzi, C; Taliani, G; Guedj, J; Perno, Cf; CECCHERINI SILBERSTEIN, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/182630
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