Degenerative forms of mitral valve diseases (MVDs) are very complex pathologies. Thus, it is difficult to make generalizations about the disease pathways or genetic risk factors contributing to these diseases. However, a key role of metalloproteinases (MMPs) in their pathophysiology is emerging. Thus, we performed for the first time a perspective study to assess eventual associations of some functional single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes with the MVD risk, symptom severity, and short- and long-term (4.8 years) complications.

Balistreri, C.r., Allegra, A., Crapanzano, F., Pisano, C., Triolo, O.f., Argano, V., et al. (2016). Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative mitral valve diseases: A 4.8-year prospective cohort study. CARDIOVASCULAR PATHOLOGY, 25(5), 362-370 [10.1016/j.carpath.2016.05.004].

Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative mitral valve diseases: A 4.8-year prospective cohort study

Pisano, C;RUVOLO, GIOVANNI
2016

Abstract

Degenerative forms of mitral valve diseases (MVDs) are very complex pathologies. Thus, it is difficult to make generalizations about the disease pathways or genetic risk factors contributing to these diseases. However, a key role of metalloproteinases (MMPs) in their pathophysiology is emerging. Thus, we performed for the first time a perspective study to assess eventual associations of some functional single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes with the MVD risk, symptom severity, and short- and long-term (4.8 years) complications.
Pubblicato
Rilevanza internazionale
Articolo
Esperti non anonimi
Settore MED/23 - Chirurgia Cardiaca
English
Con Impact Factor ISI
Degenerative forms of mitral valve diseases; Management and outcome; Metalloproteinases; rs3918242, rs243865, rs2285053 MMP-2 and MMP-9 gene SNPs; Aged; Cohort Studies; Female; Genetic Predisposition to Disease; Genotype; Heart Valve Diseases; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Mitral Valve; Prospective Studies; Risk Factors; Polymorphism, Single Nucleotide
Balistreri, C.r., Allegra, A., Crapanzano, F., Pisano, C., Triolo, O.f., Argano, V., et al. (2016). Associations of rs3918242 and rs2285053 MMP-9 and MMP-2 polymorphisms with the risk, severity, and short- and long-term complications of degenerative mitral valve diseases: A 4.8-year prospective cohort study. CARDIOVASCULAR PATHOLOGY, 25(5), 362-370 [10.1016/j.carpath.2016.05.004].
Balistreri, C; Allegra, A; Crapanzano, F; Pisano, C; Triolo, O; Argano, V; Candore, G; Lio, D; Ruvolo, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/181460
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