In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, capitalising on newly generated and publicly available time and geo-referenced NS3 encoding virus genetic sequence data.

Cuypers, L., Vrancken, B., Fabeni, L., Marascio, N., Cento, V., Di Maio, V.c., et al. (2017). Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy. BMC EVOLUTIONARY BIOLOGY, 17(1), 70 [10.1186/s12862-017-0913-3].

Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy

FABENI, LAVINIA;CENTO, VALERIA;DI MAIO, VELIA CHIARA;PERNO, CARLO FEDERICO;CECCHERINI SILBERSTEIN, FRANCESCA
2017

Abstract

In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, capitalising on newly generated and publicly available time and geo-referenced NS3 encoding virus genetic sequence data.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - Microbiologia e Microbiologia Clinica
eng
Con Impact Factor ISI
Europe; HCV; HCV1a; Italy; Phylogeography; Public health policy; Q80K; US
Cuypers, L., Vrancken, B., Fabeni, L., Marascio, N., Cento, V., Di Maio, V.c., et al. (2017). Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy. BMC EVOLUTIONARY BIOLOGY, 17(1), 70 [10.1186/s12862-017-0913-3].
Cuypers, L; Vrancken, B; Fabeni, L; Marascio, N; Cento, V; DI MAIO, Vc; Aragri, M; Pineda Pena, A; Schrooten, Y; Van Laethem, K; Balog, D; Foca, A; Torti, C; Nevens, F; Perno, Cf; Vandamme, A; CECCHERINI SILBERSTEIN, F
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/181444
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 15
social impact