In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, capitalising on newly generated and publicly available time and geo-referenced NS3 encoding virus genetic sequence data.
Cuypers, L., Vrancken, B., Fabeni, L., Marascio, N., Cento, V., DI MAIO, V.c., et al. (2017). Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy. BMC EVOLUTIONARY BIOLOGY, 17(1), 70 [10.1186/s12862-017-0913-3].
Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy
FABENI, LAVINIA;CENTO, VALERIA;DI MAIO, VELIA CHIARA;PERNO, CARLO FEDERICO;CECCHERINI SILBERSTEIN, FRANCESCA
2017-01-01
Abstract
In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, capitalising on newly generated and publicly available time and geo-referenced NS3 encoding virus genetic sequence data.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
