First-generation protease-inhibitors (PIs) had suboptimal efficacy in GT-1 patients with advanced liver disease, and those who failed may need urgent retreatment. Our objective was to analyze the real-life efficacy of interferon (IFN)-free retreatment after PI-failure, and the role of genotypic-resistance-testing (GRT) in guiding retreatment choice.

Cento, V., Barbaliscia, S., Lenci, I., Ruggiero, T., Magni, C., Paolucci, S., et al. (2017). Optimal efficacy of interferon-free HCV retreatment after protease inhibitors failure in real life. CLINICAL MICROBIOLOGY AND INFECTION [10.1016/j.cmi.2017.04.005].

Optimal efficacy of interferon-free HCV retreatment after protease inhibitors failure in real life

CENTO, VALERIA;BARBALISCIA, SILVIA;LENCI, ILARIA;PERNO, CARLO FEDERICO;CECCHERINI SILBERSTEIN, FRANCESCA
2017-04-12

Abstract

First-generation protease-inhibitors (PIs) had suboptimal efficacy in GT-1 patients with advanced liver disease, and those who failed may need urgent retreatment. Our objective was to analyze the real-life efficacy of interferon (IFN)-free retreatment after PI-failure, and the role of genotypic-resistance-testing (GRT) in guiding retreatment choice.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - Microbiologia e Microbiologia Clinica
English
Con Impact Factor ISI
Cirrhosis; DIrect acting antivirals; Genotypic resistance testing; HCVFailure; NS5A-inhibitors; Protease-inhibitors; Retreatment; hcv-resistance
The funders had no role in study design, data collection and 168 analysis, decision to publish, or preparation of the manuscript.
Cento, V., Barbaliscia, S., Lenci, I., Ruggiero, T., Magni, C., Paolucci, S., et al. (2017). Optimal efficacy of interferon-free HCV retreatment after protease inhibitors failure in real life. CLINICAL MICROBIOLOGY AND INFECTION [10.1016/j.cmi.2017.04.005].
Cento, V; Barbaliscia, S; Lenci, I; Ruggiero, T; Magni, C; Paolucci, S; Babudieri, S; Siciliano, M; Pasquazzi, C; Ciancio, A; Perno, Cf; CECCHERINI SILBERSTEIN, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/181428
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