The immunomodulatory activity of thymosin α1 (Tα1) on innate immunity has been extensively described, but its mechanism of action is not completely understood. We explored the possibility that Tα1-stimulation could affect the formation of podosomes, the highly dynamic, actin-rich, adhesion structures involved in macrophage adhesion/chemotaxis.

Serafino, A., Andreola, F., Pittaluga, E., Krasnowska, E., Nicotera, G., Sferrazza, G., et al. (2015). Thymosin α1 modifies podosome architecture and promptly stimulates the expression of podosomal markers in mature macrophages. EXPERT OPINION ON BIOLOGICAL THERAPY, 15(sup1), S101-S116 [10.1517/14712598.2015.1024221].

Thymosin α1 modifies podosome architecture and promptly stimulates the expression of podosomal markers in mature macrophages

ANDREOLA, FEDERICA;GARACI, ENRICO
2015-01-01

Abstract

The immunomodulatory activity of thymosin α1 (Tα1) on innate immunity has been extensively described, but its mechanism of action is not completely understood. We explored the possibility that Tα1-stimulation could affect the formation of podosomes, the highly dynamic, actin-rich, adhesion structures involved in macrophage adhesion/chemotaxis.
2015
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
confocal microscopy; cytoskeletal components; macrophages; podosomes; thymosin α1; Actins; Biomarkers; Cell Movement; Cells, Cultured; Humans; Immunity, Innate; Leukocytes, Mononuclear; Macrophages; Podosomes; Thymosin; Vinculin
Serafino, A., Andreola, F., Pittaluga, E., Krasnowska, E., Nicotera, G., Sferrazza, G., et al. (2015). Thymosin α1 modifies podosome architecture and promptly stimulates the expression of podosomal markers in mature macrophages. EXPERT OPINION ON BIOLOGICAL THERAPY, 15(sup1), S101-S116 [10.1517/14712598.2015.1024221].
Serafino, A; Andreola, F; Pittaluga, E; Krasnowska, E; Nicotera, G; Sferrazza, G; Vallebona, P; Pierimarchi, P; Garaci, E
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/181037
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