Plasmodium falciparum placental infection primes the fetal immune system and alters infant immunity. Mechanisms leading to these outcomes are not completely understood. We focused on Vγ2Vδ2 cells, which are part of the immune response against many pathogens, including P. falciparum. These unconventional lymphocytes respond directly to small, nonpeptidic antigens, independent of major histocompatibility complex presentation. We wondered whether placental malaria, which may increase fetal exposure to P. falciparum metabolites, triggers a response by neonatal Vγ2Vδ2 lymphocytes that can be a marker for the extent of fetal exposure to malarial antigens.

Cairo, C., Longinaker, N., Cappelli, G., Leke, R., Ondo, M., Djokam, R., et al. (2014). Cord blood V2Vδ2 T cells provide a molecular marker for the influence of pregnancy-associated malaria on neonatal immunity. THE JOURNAL OF INFECTIOUS DISEASES, 209(10), 1653-1662 [10.1093/infdis/jit802].

Cord blood V2Vδ2 T cells provide a molecular marker for the influence of pregnancy-associated malaria on neonatal immunity

COLIZZI, VITTORIO;
2014-01-01

Abstract

Plasmodium falciparum placental infection primes the fetal immune system and alters infant immunity. Mechanisms leading to these outcomes are not completely understood. We focused on Vγ2Vδ2 cells, which are part of the immune response against many pathogens, including P. falciparum. These unconventional lymphocytes respond directly to small, nonpeptidic antigens, independent of major histocompatibility complex presentation. We wondered whether placental malaria, which may increase fetal exposure to P. falciparum metabolites, triggers a response by neonatal Vγ2Vδ2 lymphocytes that can be a marker for the extent of fetal exposure to malarial antigens.
2014
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - PATOLOGIA GENERALE
English
Con Impact Factor ISI
Plasmodium; aminobisphosphonate; cord blood; gammadelta; innate; neonatal; phosphoantigen; placental malaria; repertoire; Biomarkers; Female; Fetal Blood; Gene Expression Regulation; Humans; Immunoglobulin gamma-Chains; Infant, Newborn; Malaria, Falciparum; Pregnancy; Pregnancy Complications, Parasitic; T-Lymphocyte Subsets; Immunity, Maternally-Acquired
Cairo, C., Longinaker, N., Cappelli, G., Leke, R., Ondo, M., Djokam, R., et al. (2014). Cord blood V2Vδ2 T cells provide a molecular marker for the influence of pregnancy-associated malaria on neonatal immunity. THE JOURNAL OF INFECTIOUS DISEASES, 209(10), 1653-1662 [10.1093/infdis/jit802].
Cairo, C; Longinaker, N; Cappelli, G; Leke, R; Ondo, M; Djokam, R; Fogako, J; Leke, R; Sagnia, B; Sosso, S; Colizzi, V; Pauza, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/180750
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