A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.
Ranallo, S., Prévost Tremblay, C., Idili, A., Vallée Bélisle, A., & Ricci, F. (2017). Antibody-powered nucleic acid release using a DNA-based nanomachine. NATURE COMMUNICATIONS, 8, 15150 [10.1038/ncomms15150].
|Tipologia:||Articolo su rivista|
|Citazione:||Ranallo, S., Prévost Tremblay, C., Idili, A., Vallée Bélisle, A., & Ricci, F. (2017). Antibody-powered nucleic acid release using a DNA-based nanomachine. NATURE COMMUNICATIONS, 8, 15150 [10.1038/ncomms15150].|
|Settore Scientifico Disciplinare:||Settore CHIM/01 - Chimica Analitica|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/ncomms15150|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2017|
|Titolo:||Antibody-powered nucleic acid release using a DNA-based nanomachine|
|Autori:||Ranallo, S; Prévost Tremblay, C; Idili, A; Vallée Bélisle, A; Ricci, F|
|Appare nelle tipologie:||01 - Articolo su rivista|