We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and SAT. However, miR21 expression was two folds greater in adipose tissue in patients with T2D. Accordingly, in primary cultures of adipocytes from non diabetic overweight subjects, miR21 expression increased after 24-h exposure to high glucose and insulin. In conclusion, miR21 appears linked to insulin-resistance deterioration within its pathophysiologic progression from obesity to T2D.

Guglielmi, V., D'Adamo, M., Menghini, R., Cardellini, M., Gentileschi, P., Federici, M., et al. (2017). MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects. NUTRITION AND HEALTHY AGING, 4(2), 141-145 [10.3233/NHA-160020].

MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects

Guglielmi, V
Writing – Original Draft Preparation
;
D'Adamo, M
Writing – Review & Editing
;
Menghini, R
Membro del Collaboration Group
;
Cardellini, M
Membro del Collaboration Group
;
Gentileschi, P
Membro del Collaboration Group
;
Federici, M
Membro del Collaboration Group
;
Sbraccia, P.
Supervision
2017-03-31

Abstract

We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and SAT. However, miR21 expression was two folds greater in adipose tissue in patients with T2D. Accordingly, in primary cultures of adipocytes from non diabetic overweight subjects, miR21 expression increased after 24-h exposure to high glucose and insulin. In conclusion, miR21 appears linked to insulin-resistance deterioration within its pathophysiologic progression from obesity to T2D.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - Medicina Interna
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
Settore MED/18 - Chirurgia Generale
English
Micro RNA; human adipocyte; miR21; obesity; omental adipose tissue; subcutaneous adipose tissue; type 2 diabetes
Guglielmi, V., D'Adamo, M., Menghini, R., Cardellini, M., Gentileschi, P., Federici, M., et al. (2017). MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects. NUTRITION AND HEALTHY AGING, 4(2), 141-145 [10.3233/NHA-160020].
Guglielmi, V; D'Adamo, M; Menghini, R; Cardellini, M; Gentileschi, P; Federici, M; Sbraccia, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/179992
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