A method to control activation of a DNA nanodevice by supplying a complementary DNA (cDNA) strand from an electro-responsive nanoplatform is reported. To develop functional nanoplatform, hexalayer nanofilm is precisely designed by layer-by-layer assembly technique based on electrostatic interaction with four kinds of materials: Hydrolyzed poly(β-amino ester) can help cDNA release from the film. A cDNA is used as a key building block to activate DNA nanodevice. Reduced graphene oxides (rGOs) and the conductive polymer provide conductivity. In particular, rGOs efficiently incorporate a cDNA in the film via several interactions and act as a barrier. Depending on the types of applied electronic stimuli (reductive and oxidative potentials), a cDNA released from the electrode can quantitatively control the activation of DNA nanodevice. From this report, a new system is successfully demonstrated to precisely control DNA release on demand. By applying more advanced form of DNA-based nanodevices into multilayer system, the electro-responsive nanoplatform will expand the availability of DNA nanotechnology allowing its improved application in areas such as diagnosis, biosensing, bioimaging, and drug delivery.
Jeong, H., Ranallo, S., Rossetti, M., Heo, J., Shin, J., Park, K., et al. (2016). Electronic Activation of a DNA Nanodevice Using a Multilayer Nanofilm. SMALL, 12(40), 5572-5578 [10.1002/smll.201601273].
|Tipologia:||Articolo su rivista|
|Citazione:||Jeong, H., Ranallo, S., Rossetti, M., Heo, J., Shin, J., Park, K., et al. (2016). Electronic Activation of a DNA Nanodevice Using a Multilayer Nanofilm. SMALL, 12(40), 5572-5578 [10.1002/smll.201601273].|
|Settore Scientifico Disciplinare:||Settore CHIM/01 - Chimica Analitica|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/smll.201601273|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||20-giu-2016|
|Titolo:||Electronic Activation of a DNA Nanodevice Using a Multilayer Nanofilm|
|Autori:||Jeong, H; Ranallo, S; Rossetti, M; Heo, J; Shin, J; Park, K; Ricci, F; Hong, J|
|Appare nelle tipologie:||01 - Articolo su rivista|