A method to control activation of a DNA nanodevice by supplying a complementary DNA (cDNA) strand from an electro-responsive nanoplatform is reported. To develop functional nanoplatform, hexalayer nanofilm is precisely designed by layer-by-layer assembly technique based on electrostatic interaction with four kinds of materials: Hydrolyzed poly(β-amino ester) can help cDNA release from the film. A cDNA is used as a key building block to activate DNA nanodevice. Reduced graphene oxides (rGOs) and the conductive polymer provide conductivity. In particular, rGOs efficiently incorporate a cDNA in the film via several interactions and act as a barrier. Depending on the types of applied electronic stimuli (reductive and oxidative potentials), a cDNA released from the electrode can quantitatively control the activation of DNA nanodevice. From this report, a new system is successfully demonstrated to precisely control DNA release on demand. By applying more advanced form of DNA-based nanodevices into multilayer system, the electro-responsive nanoplatform will expand the availability of DNA nanotechnology allowing its improved application in areas such as diagnosis, biosensing, bioimaging, and drug delivery.

Jeong, H., Ranallo, S., Rossetti, M., Heo, J., Shin, J., Park, K., et al. (2016). Electronic Activation of a DNA Nanodevice Using a Multilayer Nanofilm. SMALL, 12(40), 5572-5578 [10.1002/smll.201601273].

Electronic Activation of a DNA Nanodevice Using a Multilayer Nanofilm

RANALLO, SIMONA;ROSSETTI, MARIANNA;RICCI, FRANCESCO;
2016-06-20

Abstract

A method to control activation of a DNA nanodevice by supplying a complementary DNA (cDNA) strand from an electro-responsive nanoplatform is reported. To develop functional nanoplatform, hexalayer nanofilm is precisely designed by layer-by-layer assembly technique based on electrostatic interaction with four kinds of materials: Hydrolyzed poly(β-amino ester) can help cDNA release from the film. A cDNA is used as a key building block to activate DNA nanodevice. Reduced graphene oxides (rGOs) and the conductive polymer provide conductivity. In particular, rGOs efficiently incorporate a cDNA in the film via several interactions and act as a barrier. Depending on the types of applied electronic stimuli (reductive and oxidative potentials), a cDNA released from the electrode can quantitatively control the activation of DNA nanodevice. From this report, a new system is successfully demonstrated to precisely control DNA release on demand. By applying more advanced form of DNA-based nanodevices into multilayer system, the electro-responsive nanoplatform will expand the availability of DNA nanotechnology allowing its improved application in areas such as diagnosis, biosensing, bioimaging, and drug delivery.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/01 - Chimica Analitica
English
Jeong, H., Ranallo, S., Rossetti, M., Heo, J., Shin, J., Park, K., et al. (2016). Electronic Activation of a DNA Nanodevice Using a Multilayer Nanofilm. SMALL, 12(40), 5572-5578 [10.1002/smll.201601273].
Jeong, H; Ranallo, S; Rossetti, M; Heo, J; Shin, J; Park, K; Ricci, F; Hong, J
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/179749
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