Inflammation and oxidative damage contribute significantly to the development of cardiovascular diseases (CVD). Postprandial oxidative stress and inflammation are characterized by an increased susceptibility of the organism toward oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Micronutrients modulate immune system and exert a protective action by reducing oxidized low-density lipoprotein (ox-LDL) level. The aim of the present study was to evaluate the postprandial plasma ox-LDL level and the gene expression of 13 genes related to oxidative stress (HOSp) and human inflammasome pathways (HIp), after a tocopherol-enriched Mediterranean meal (TEM), and a Western high-fat meal (HFM). Moreover, Mediterranean Adequacy Index was calculated to define the quality of both meals.

DE LORENZO, A., Bernardini, S., Gualtieri, P., Cabibbo, A., Perrone, M., Giambini, I., et al. (2017). Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk. ACTA DIABETOLOGICA, 54(2), 141-149 [10.1007/s00592-016-0917-2].

Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk

DE LORENZO, ANTONINO;Bernardini, S;GUALTIERI, PAOLA;CABIBBO, ANDREA;Perrone, Ma;DI RENZO, LAURA
2017-02-01

Abstract

Inflammation and oxidative damage contribute significantly to the development of cardiovascular diseases (CVD). Postprandial oxidative stress and inflammation are characterized by an increased susceptibility of the organism toward oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Micronutrients modulate immune system and exert a protective action by reducing oxidized low-density lipoprotein (ox-LDL) level. The aim of the present study was to evaluate the postprandial plasma ox-LDL level and the gene expression of 13 genes related to oxidative stress (HOSp) and human inflammasome pathways (HIp), after a tocopherol-enriched Mediterranean meal (TEM), and a Western high-fat meal (HFM). Moreover, Mediterranean Adequacy Index was calculated to define the quality of both meals.
feb-2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Con Impact Factor ISI
CVD; Mediterranean meal; Nutrigenomic; Oxidized-LDL; Adult; Biomarkers; Cardiovascular Diseases; Diet, Mediterranean; Diet, Western; Female; Humans; Inflammation; Lipoproteins, LDL; Male; Metabolic Syndrome X; Oxidative Stress; Postprandial Period; Nutrigenomics
https://link.springer.com/article/10.1007%2Fs00592-016-0917-2
DE LORENZO, A., Bernardini, S., Gualtieri, P., Cabibbo, A., Perrone, M., Giambini, I., et al. (2017). Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk. ACTA DIABETOLOGICA, 54(2), 141-149 [10.1007/s00592-016-0917-2].
DE LORENZO, A; Bernardini, S; Gualtieri, P; Cabibbo, A; Perrone, M; Giambini, I; DI RENZO, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/179725
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