Inflammation and oxidative damage contribute significantly to the development of cardiovascular diseases (CVD). Postprandial oxidative stress and inflammation are characterized by an increased susceptibility of the organism toward oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Micronutrients modulate immune system and exert a protective action by reducing oxidized low-density lipoprotein (ox-LDL) level. The aim of the present study was to evaluate the postprandial plasma ox-LDL level and the gene expression of 13 genes related to oxidative stress (HOSp) and human inflammasome pathways (HIp), after a tocopherol-enriched Mediterranean meal (TEM), and a Western high-fat meal (HFM). Moreover, Mediterranean Adequacy Index was calculated to define the quality of both meals.

DE LORENZO, A., Bernardini, S., Gualtieri, P., Cabibbo, A., Perrone, M., Giambini, I., et al. (2017). Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk. ACTA DIABETOLOGICA, 54(2), 141-149 [10.1007/s00592-016-0917-2].

Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk

DE LORENZO, ANTONINO;Bernardini, S;GUALTIERI, PAOLA;CABIBBO, ANDREA;DI RENZO, LAURA
2017-02

Abstract

Inflammation and oxidative damage contribute significantly to the development of cardiovascular diseases (CVD). Postprandial oxidative stress and inflammation are characterized by an increased susceptibility of the organism toward oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Micronutrients modulate immune system and exert a protective action by reducing oxidized low-density lipoprotein (ox-LDL) level. The aim of the present study was to evaluate the postprandial plasma ox-LDL level and the gene expression of 13 genes related to oxidative stress (HOSp) and human inflammasome pathways (HIp), after a tocopherol-enriched Mediterranean meal (TEM), and a Western high-fat meal (HFM). Moreover, Mediterranean Adequacy Index was calculated to define the quality of both meals.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
English
Con Impact Factor ISI
CVD; Mediterranean meal; Nutrigenomic; Oxidized-LDL; Adult; Biomarkers; Cardiovascular Diseases; Diet, Mediterranean; Diet, Western; Female; Humans; Inflammation; Lipoproteins, LDL; Male; Metabolic Syndrome X; Oxidative Stress; Postprandial Period; Nutrigenomics
https://link.springer.com/article/10.1007%2Fs00592-016-0917-2
DE LORENZO, A., Bernardini, S., Gualtieri, P., Cabibbo, A., Perrone, M., Giambini, I., et al. (2017). Mediterranean meal versus Western meal effects on postprandial ox-LDL, oxidative and inflammatory gene expression in healthy subjects: a randomized controlled trial for nutrigenomic approach in cardiometabolic risk. ACTA DIABETOLOGICA, 54(2), 141-149 [10.1007/s00592-016-0917-2].
DE LORENZO, A; Bernardini, S; Gualtieri, P; Cabibbo, A; Perrone, M; Giambini, I; DI RENZO, L
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
art%3A10.1007%2Fs00592-016-0917-2.pdf

accesso solo dalla rete interna

Descrizione: articolo principale
Licenza: Copyright dell'editore
Dimensione 655.38 kB
Formato Adobe PDF
655.38 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/179725
Citazioni
  • ???jsp.display-item.citation.pmc??? 24
  • Scopus 42
  • ???jsp.display-item.citation.isi??? 38
social impact