Few radiopharmaceuticals have been described for the study of lymphocyte trafficking despite its high clinical relevance. The main difficulty resides in the identification of a suitable highly specific probe to target these cells. Interleukin-12 (IL12) is a heterodimeric cytokine which plays a key role in the development of Th(1) lymphocytes. The aims of the present study were to label IL12 with (99m)Tc, to evaluate its ability to bind to activated T lymphocytes in vitro and to study its biodistribution in normal mice and mice affected by autoimmune colitis.

Annovazzi, A., D'Alessandria, C., Bonanno, E., Mather, S., Cornelissen, B., van de Wiele, C., et al. (2006). Synthesis of 99mTc-HYNIC-interleukin-12, a new specific radiopharmaceutical for imaging T lymphocytes. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 33(4), 474-482 [10.1007/s00259-005-0001-6].

Synthesis of 99mTc-HYNIC-interleukin-12, a new specific radiopharmaceutical for imaging T lymphocytes

BONANNO, ELENA;MATTEI, MAURIZIO;
2006-04-01

Abstract

Few radiopharmaceuticals have been described for the study of lymphocyte trafficking despite its high clinical relevance. The main difficulty resides in the identification of a suitable highly specific probe to target these cells. Interleukin-12 (IL12) is a heterodimeric cytokine which plays a key role in the development of Th(1) lymphocytes. The aims of the present study were to label IL12 with (99m)Tc, to evaluate its ability to bind to activated T lymphocytes in vitro and to study its biodistribution in normal mice and mice affected by autoimmune colitis.
apr-2006
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - PATOLOGIA GENERALE
English
Con Impact Factor ISI
Male; Organ Specificity; Cell Line; Organotechnetium Compounds; Colitis; Feasibility Studies; Animals; T-Lymphocytes; Isotope Labeling; Radiopharmaceuticals; Mice; Interleukin-12; Tissue Distribution; Metabolic Clearance Rate
Annovazzi, A., D'Alessandria, C., Bonanno, E., Mather, S., Cornelissen, B., van de Wiele, C., et al. (2006). Synthesis of 99mTc-HYNIC-interleukin-12, a new specific radiopharmaceutical for imaging T lymphocytes. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 33(4), 474-482 [10.1007/s00259-005-0001-6].
Annovazzi, A; D'Alessandria, C; Bonanno, E; Mather, S; Cornelissen, B; van de Wiele, C; Dierckx, R; Mattei, M; Palmieri, G; Scopinaro, F; Signore, A...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/17897
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