Excision repair cross-complementation group 1 (ERCC1) is a key component in DNA repair mechanisms and may influence the tumor DNA-targeting effect of the chemotherapeutic agent oxaliplatin. Germline ERCC1 polymorphisms may alter the protein expression and published data on their predictive and prognostic value have so far been contradictory. In the present article we review available evidence on the clinical role and utility of ERCC1 polymorphisms and, in the absence of a 'perfect' trial, what we call the 'sliding doors' trial, we present the data of ERCC1 genotyping in our local patient population. We found a useful predictive value for oxaliplatin-induced risk of anemia.
Formica, V., Doldo, E., Antonetti, F., Nardecchia, A., Ferroni, P., Riondino, S., et al. (2017). Biological and predictive role of ERCC1 polymorphisms in cancer. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 111, 133-143 [10.1016/j.critrevonc.2017.01.016].
Biological and predictive role of ERCC1 polymorphisms in cancer
FORMICA, VINCENZO;DOLDO, ELENA;Riondino, S;ORLANDI, AUGUSTO;ROSELLI, MARIO
2017-01-01
Abstract
Excision repair cross-complementation group 1 (ERCC1) is a key component in DNA repair mechanisms and may influence the tumor DNA-targeting effect of the chemotherapeutic agent oxaliplatin. Germline ERCC1 polymorphisms may alter the protein expression and published data on their predictive and prognostic value have so far been contradictory. In the present article we review available evidence on the clinical role and utility of ERCC1 polymorphisms and, in the absence of a 'perfect' trial, what we call the 'sliding doors' trial, we present the data of ERCC1 genotyping in our local patient population. We found a useful predictive value for oxaliplatin-induced risk of anemia.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
