Adenosine inhibits the immune response in tumors. Adenosine deaminase (ADA) controls adenosine level and as ecto-enzyme acts as costimulatory molecule of adenosine receptors and/or CD26. We examined ADA₁, ADA₂, ADA₆ polymorphic sites of ADA gene in 109 subjects with colon cancer from Rome's population and in 246 blood donors as controls from the same population. In colon cancer ADA₁*2/ADA₂*1 haplotype is more represented, while ADA₁*2/ADA₂*2 is less represented than in controls. ADA₂*2/ADA₆*2 is less represented in patients than in controls. Polymorphic sites of ADA might influence cell-mediated anti-tumor immune responses controlling adenosine level and extraenzymatic protein functions.

Spina, C., Saccucci, P., Cozzoli, E., Bottini, E., Gloria, F. (2010). A study of three polymorphic sites of ADA gene in colon cancer. CANCER INVESTIGATION, 28(10), 989-992 [10.3109/07357907.2010.483501].

A study of three polymorphic sites of ADA gene in colon cancer

SPINA, CLAUDIO;SACCUCCI, PATRIZIA;BOTTINI, EGIDIO;GLORIA, FULVIA
2010-12-01

Abstract

Adenosine inhibits the immune response in tumors. Adenosine deaminase (ADA) controls adenosine level and as ecto-enzyme acts as costimulatory molecule of adenosine receptors and/or CD26. We examined ADA₁, ADA₂, ADA₆ polymorphic sites of ADA gene in 109 subjects with colon cancer from Rome's population and in 246 blood donors as controls from the same population. In colon cancer ADA₁*2/ADA₂*1 haplotype is more represented, while ADA₁*2/ADA₂*2 is less represented than in controls. ADA₂*2/ADA₆*2 is less represented in patients than in controls. Polymorphic sites of ADA might influence cell-mediated anti-tumor immune responses controlling adenosine level and extraenzymatic protein functions.
dic-2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/01 - STATISTICA MEDICA
English
Con Impact Factor ISI
Male; Adenosine; Female; Polymorphism, Single Nucleotide; Polymerase Chain Reaction; Aged; Genotype; Colonic Neoplasms; Polymorphism, Restriction Fragment Length; Adenosine Deaminase; Humans
Spina, C., Saccucci, P., Cozzoli, E., Bottini, E., Gloria, F. (2010). A study of three polymorphic sites of ADA gene in colon cancer. CANCER INVESTIGATION, 28(10), 989-992 [10.3109/07357907.2010.483501].
Spina, C; Saccucci, P; Cozzoli, E; Bottini, E; Gloria, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/17759
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