Proper adipose tissue function controls energy balance with favourable effects on metabolic health and longevity. The molecular and metabolic asset of adipose tissue quickly and dynamically readapts in response to nutrient fluctuations. Once delivered into cells, nutrients are managed by mitochondria that represent a key bioenergetics node. A persistent nutrient overload generates mitochondrial exhaustion and uncontrolled reactive oxygen species ((mt)ROS) production. In adipocytes, metabolic/molecular reorganization is triggered culminating in the acquirement of a hypertrophic and hypersecretory phenotype that accelerates aging. Conversely, dietary regimens such as caloric restriction or time-controlled fasting endorse mitochondrial functionality and (mt)ROS-mediated signalling, thus promoting geroprotection. In this perspective view, we argued some important molecular and metabolic aspects related to adipocyte response to nutrient stress. Finally we delineated hypothetical routes by which molecularly and metabolically readapted adipose tissue promotes healthy aging.
Lettieri Barbato, D., & Aquilano, K. (2016). Feast and famine: Adipose tissue adaptations for healthy aging. AGEING RESEARCH REVIEWS, 28, 85-93.
|Tipologia:||Articolo su rivista|
|Citazione:||Lettieri Barbato, D., & Aquilano, K. (2016). Feast and famine: Adipose tissue adaptations for healthy aging. AGEING RESEARCH REVIEWS, 28, 85-93.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/49 - Scienze Tecniche Dietetiche Applicate|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.arr.2016.05.007|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2016|
|Titolo:||Feast and famine: Adipose tissue adaptations for healthy aging|
|Autori:||Lettieri Barbato, D; Aquilano, K|
|Appare nelle tipologie:||01 - Articolo su rivista|