Proper adipose tissue function controls energy balance with favourable effects on metabolic health and longevity. The molecular and metabolic asset of adipose tissue quickly and dynamically readapts in response to nutrient fluctuations. Once delivered into cells, nutrients are managed by mitochondria that represent a key bioenergetics node. A persistent nutrient overload generates mitochondrial exhaustion and uncontrolled reactive oxygen species ((mt)ROS) production. In adipocytes, metabolic/molecular reorganization is triggered culminating in the acquirement of a hypertrophic and hypersecretory phenotype that accelerates aging. Conversely, dietary regimens such as caloric restriction or time-controlled fasting endorse mitochondrial functionality and (mt)ROS-mediated signalling, thus promoting geroprotection. In this perspective view, we argued some important molecular and metabolic aspects related to adipocyte response to nutrient stress. Finally we delineated hypothetical routes by which molecularly and metabolically readapted adipose tissue promotes healthy aging.

Lettieri Barbato, D., & Aquilano, K. (2016). Feast and famine: Adipose tissue adaptations for healthy aging. AGEING RESEARCH REVIEWS, 28, 85-93 [10.1016/j.arr.2016.05.007].

Feast and famine: Adipose tissue adaptations for healthy aging

LETTIERI BARBATO, DANIELE;AQUILANO, KATIA
2016

Abstract

Proper adipose tissue function controls energy balance with favourable effects on metabolic health and longevity. The molecular and metabolic asset of adipose tissue quickly and dynamically readapts in response to nutrient fluctuations. Once delivered into cells, nutrients are managed by mitochondria that represent a key bioenergetics node. A persistent nutrient overload generates mitochondrial exhaustion and uncontrolled reactive oxygen species ((mt)ROS) production. In adipocytes, metabolic/molecular reorganization is triggered culminating in the acquirement of a hypertrophic and hypersecretory phenotype that accelerates aging. Conversely, dietary regimens such as caloric restriction or time-controlled fasting endorse mitochondrial functionality and (mt)ROS-mediated signalling, thus promoting geroprotection. In this perspective view, we argued some important molecular and metabolic aspects related to adipocyte response to nutrient stress. Finally we delineated hypothetical routes by which molecularly and metabolically readapted adipose tissue promotes healthy aging.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
English
Con Impact Factor ISI
FoxO1; Lipid metabolism; Longevity; Mitochondria; Nutrient
Lettieri Barbato, D., & Aquilano, K. (2016). Feast and famine: Adipose tissue adaptations for healthy aging. AGEING RESEARCH REVIEWS, 28, 85-93 [10.1016/j.arr.2016.05.007].
LETTIERI BARBATO, D; Aquilano, K
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/176611
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