The Italian Dystonia Registry is a multicenter data collection system that will prospectively assess the phenomenology and natural history of adult-onset dystonia and will serve as a basis for future etiological, pathophysiological and therapeutic studies. In the first 6 months of activity, 20 movement disorders Italian centres have adhered to the registry and 664 patients have been recruited. Baseline historical information from this cohort provides the first general overview of adult-onset dystonia in Italy. The cohort was characterized by a lower education level than the Italian population, and most patients were employed as artisans, builders, farmers, or unskilled workers. The clinical features of our sample confirmed the peculiar characteristics of adult-onset dystonia, i.e. gender preference, peak age at onset in the sixth decade, predominance of cervical dystonia and blepharospasm over the other focal dystonias, and a tendency to spread to adjacent body parts, The sample also confirmed the association between eye symptoms and blepharospasm, whereas no clear association emerged between extracranial injury and dystonia in a body site. Adult-onset dystonia patients and the Italian population shared similar burden of arterial hypertension, type 2 diabetes, coronary heart disease, dyslipidemia, and hypothyroidism, while hyperthyroidism was more frequent in the dystonia population. Geographic stratification of the study population yielded no major difference in the most clinical and phenomenological features of dystonia. Analysis of baseline information from recruited patients indicates that the Italian Dystonia Registry may be a useful tool to capture the real world clinical practice of physicians that visit dystonia patients.
Defazio, G., Esposito, M., Abbruzzese, G., Scaglione, C., Fabbrini, G., Ferrazzano, G., et al. (2017). The Italian Dystonia Registry: rationale, design and preliminary findings. NEUROLOGICAL SCIENCES, 38(5), 819-825 [10.1007/s10072-017-2839-3].
|Tipologia:||Articolo su rivista|
|Citazione:||Defazio, G., Esposito, M., Abbruzzese, G., Scaglione, C., Fabbrini, G., Ferrazzano, G., et al. (2017). The Italian Dystonia Registry: rationale, design and preliminary findings. NEUROLOGICAL SCIENCES, 38(5), 819-825 [10.1007/s10072-017-2839-3].|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10072-017-2839-3|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||mag-2017|
|Titolo:||The Italian Dystonia Registry: rationale, design and preliminary findings|
|Autori:||Defazio, G; Esposito, M; Abbruzzese, G; Scaglione, C; Fabbrini, G; Ferrazzano, G; Peluso, S; Pellicciari, R; Gigante, A; Cossu, G; Arca, R; Avanzino, L; Bono, F; Mazza, M; Bertolasi, L; Bacchin, R; Eleopra, R; Lettieri, C; Morgante, F; Altavista, M; Polidori, L; Liguori, R; Misceo, S; Squintani, G; Tinazzi, M; Ceravolo, R; Unti, E; Magistrelli, L; Coletti Moja, M; Modugno, N; Petracca, M; Tambasco, N; Cotelli, M; Aguggia, M; Pisani, A; Romano, M; Zibetti, M; Bentivoglio, A; Albanese, A; Girlanda, P; Berardelli, A|
|Appare nelle tipologie:||01 - Articolo su rivista|