T cells expressing Vgamma9Vdelta2 display lytic and proliferative responses against human immunodeficiency virus (HIV)-infected cells and release antiviral soluble factors. Chronic HIV-positive patients have deep changes in the composition and function of the circulating gammadelta T cell pool that are restored by highly active antiretroviral therapy (HAART). gammadelta T cells were analyzed during the rapid plasma HIV RNA rebound in HIV-infected patients undergoing structured treatment interruption (STI). A loss in circulating Vgamma9Vdelta2 T cells was observed, indicating that acute HIV replication may influence Vgamma9Vdelta2 homeostasis. These cells were lost among CD45RA(-)CD27(-) Vgamma9Vdelta2 T cell effectors, and a significant unresponsiveness, measured as antigen-driven interferon-gamma production, was observed during STI. After HAART resumption and consequent inhibition of HIV replication, Vgamma9Vdelta2 T cell reactivity was restored both quantitatively and functionally. These observations indicate that Vgamma9Vdelta2 T cells are activated early after active HIV replication but are rapidly lost when viremia is not controlled.

Martini, F., Poccia, F., Goletti, D., Carrara, S., Vincenti, D., D'Offizi, G., et al. (2002). Acute human immunodeficiency virus replication causes a rapid and persistent impairment of Vgamma9Vdelta2 T cells in chronically infected patients undergoing structured treatment interruption. THE JOURNAL OF INFECTIOUS DISEASES, 186(6), 847-850 [10.1086/342410].

Acute human immunodeficiency virus replication causes a rapid and persistent impairment of Vgamma9Vdelta2 T cells in chronically infected patients undergoing structured treatment interruption

COLIZZI, VITTORIO;MONTESANO, CARLA
2002-09-15

Abstract

T cells expressing Vgamma9Vdelta2 display lytic and proliferative responses against human immunodeficiency virus (HIV)-infected cells and release antiviral soluble factors. Chronic HIV-positive patients have deep changes in the composition and function of the circulating gammadelta T cell pool that are restored by highly active antiretroviral therapy (HAART). gammadelta T cells were analyzed during the rapid plasma HIV RNA rebound in HIV-infected patients undergoing structured treatment interruption (STI). A loss in circulating Vgamma9Vdelta2 T cells was observed, indicating that acute HIV replication may influence Vgamma9Vdelta2 homeostasis. These cells were lost among CD45RA(-)CD27(-) Vgamma9Vdelta2 T cell effectors, and a significant unresponsiveness, measured as antigen-driven interferon-gamma production, was observed during STI. After HAART resumption and consequent inhibition of HIV replication, Vgamma9Vdelta2 T cell reactivity was restored both quantitatively and functionally. These observations indicate that Vgamma9Vdelta2 T cells are activated early after active HIV replication but are rapidly lost when viremia is not controlled.
15-set-2002
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - PATOLOGIA GENERALE
English
Con Impact Factor ISI
Receptors, Antigen, T-Cell, gamma-delta; RNA, Viral; CD4-CD8 Ratio; HIV Infections; Virus Replication; T-Lymphocytes; CD8-Positive T-Lymphocytes; Humans; Flow Cytometry; Kinetics; Chronic Disease; Viral Load; Antiretroviral Therapy, Highly Active; Gene Expression Regulation; CD4-Positive T-Lymphocytes; HIV
Martini, F., Poccia, F., Goletti, D., Carrara, S., Vincenti, D., D'Offizi, G., et al. (2002). Acute human immunodeficiency virus replication causes a rapid and persistent impairment of Vgamma9Vdelta2 T cells in chronically infected patients undergoing structured treatment interruption. THE JOURNAL OF INFECTIOUS DISEASES, 186(6), 847-850 [10.1086/342410].
Martini, F; Poccia, F; Goletti, D; Carrara, S; Vincenti, D; D'Offizi, G; Agrati, C; Ippolito, G; Colizzi, V; Pucillo, L; Montesano, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/17556
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