Based upon the clinical behavior of three patients, we suggest that the combination of low-dose Ara-C and all-trans retinoic acid may potentially be effective in some elderly patients, unfit for intensive chemotherapy, affected with NPM1-mutated acute myeloid leukemia without FLT3 mutations, warranting perspective clinical studies in these selected patients.

Forghieri, F., Bigliardi, S., Quadrelli, C., Morselli, M., Potenza, L., Paolini, A., et al. (2016). All-trans retinoic acid (ATRA) in non-promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low-dose Ara-C in three elderly patients with NPM1-mutated AML unfit for intensive chemotherapy and review of the literature. CLINICAL CASE REPORTS, 4(12), 1138-1146 [10.1002/ccr3.723].

All-trans retinoic acid (ATRA) in non-promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low-dose Ara-C in three elderly patients with NPM1-mutated AML unfit for intensive chemotherapy and review of the literature

VENDITTI, ADRIANO;LO COCO, FRANCESCO;AMADORI, SERGIO;
2016-12-01

Abstract

Based upon the clinical behavior of three patients, we suggest that the combination of low-dose Ara-C and all-trans retinoic acid may potentially be effective in some elderly patients, unfit for intensive chemotherapy, affected with NPM1-mutated acute myeloid leukemia without FLT3 mutations, warranting perspective clinical studies in these selected patients.
dic-2016
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
All‐trans retinoic acid; NPM1‐mutated acute myeloid leukemia; elderly patients; low‐dose Ara‐C; unfitness for intensive chemotherapy
Forghieri, F., Bigliardi, S., Quadrelli, C., Morselli, M., Potenza, L., Paolini, A., et al. (2016). All-trans retinoic acid (ATRA) in non-promyelocytic acute myeloid leukemia (AML): results of combination of ATRA with low-dose Ara-C in three elderly patients with NPM1-mutated AML unfit for intensive chemotherapy and review of the literature. CLINICAL CASE REPORTS, 4(12), 1138-1146 [10.1002/ccr3.723].
Forghieri, F; Bigliardi, S; Quadrelli, C; Morselli, M; Potenza, L; Paolini, A; Colaci, E; Barozzi, P; Zucchini, P; Riva, G; Vallerini, D; Lagreca, I; Marasca, R; Narni, F; Venditti, A; Martelli, M; Falini, B; LO COCO, F; Amadori, S; Luppi, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/174887
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