Racemic Gossypol [(±)-GOS], composed of both (-)-GOS and (+)-GOS, is a small BH3-mimetic polyphenol derived from cotton seeds. (±)-GOS has been employed and well tolerated by cancer patients. Head and neck carcinoma (HNC) represents one of the most fatal cancers worldwide, and a significant proportion of HNC expresses high levels of antiapoptotic Bcl-2 proteins. In this study, we demonstrate that (±)-GOS inhibits cell proliferation and induces apoptosis and autophagy of human pharynx, tongue, and salivary gland cancer cell lines and of mouse salivary gland cancer cells (SALTO). (±)-GOS was able to: (a) decrease the ErbB2 protein expression; (b) inhibit the phosphorylation of ERK1/2 and AKT; (c) stimulate p38 and JNK1/2 protein phosphorylation. (±)-GOS administration was safe in BALB/c mice and it reduced the growth of transplanted SALTO cells in vivo and prolonged mice median survival. Our results suggest the potential role of (±)-GOS as an antitumor agent in HNC patients.

Benvenuto, M., Mattera, R., Masuelli, L., Taffera, G., Andracchio, O., Tresoldi, I., et al. (2017). (±)-Gossypol induces apoptosis and autophagy in head and neck carcinoma cell lines and inhibits the growth of transplanted salivary gland cancer cells in BALB/c mice. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 68(3), 1-15 [10.1080/09637486.2016.1236077].

(±)-Gossypol induces apoptosis and autophagy in head and neck carcinoma cell lines and inhibits the growth of transplanted salivary gland cancer cells in BALB/c mice

GIGANTI, MARIA GABRIELLA;MODESTI, ANDREA;BEI, ROBERTO
2017

Abstract

Racemic Gossypol [(±)-GOS], composed of both (-)-GOS and (+)-GOS, is a small BH3-mimetic polyphenol derived from cotton seeds. (±)-GOS has been employed and well tolerated by cancer patients. Head and neck carcinoma (HNC) represents one of the most fatal cancers worldwide, and a significant proportion of HNC expresses high levels of antiapoptotic Bcl-2 proteins. In this study, we demonstrate that (±)-GOS inhibits cell proliferation and induces apoptosis and autophagy of human pharynx, tongue, and salivary gland cancer cell lines and of mouse salivary gland cancer cells (SALTO). (±)-GOS was able to: (a) decrease the ErbB2 protein expression; (b) inhibit the phosphorylation of ERK1/2 and AKT; (c) stimulate p38 and JNK1/2 protein phosphorylation. (±)-GOS administration was safe in BALB/c mice and it reduced the growth of transplanted SALTO cells in vivo and prolonged mice median survival. Our results suggest the potential role of (±)-GOS as an antitumor agent in HNC patients.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - Patologia Generale
English
Con Impact Factor ISI
(±)-Gossypol; BALB/c mice; BH3-mimetic compound; Head and neck cancer; autophagy
Benvenuto, M., Mattera, R., Masuelli, L., Taffera, G., Andracchio, O., Tresoldi, I., et al. (2017). (±)-Gossypol induces apoptosis and autophagy in head and neck carcinoma cell lines and inhibits the growth of transplanted salivary gland cancer cells in BALB/c mice. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 68(3), 1-15 [10.1080/09637486.2016.1236077].
Benvenuto, M; Mattera, R; Masuelli, L; Taffera, G; Andracchio, O; Tresoldi, I; Lido, P; Giganti, Mg; Godos, J; Modesti, A; Bei, R
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/174720
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