Invasive fungal infections, usually Aspergillus and Candida, represent a major cause of morbidity and mortality in patients with malignant haematological diseases, but in the last years rare fungal infections have more frequently been reported. Here, we report the clinical history of three patients affected with haematological malignancies who developed an infection caused by Geotrichum (G.) clavatum. Two out of three patients were affected by acute myeloid leukaemia (AML), and one by mantle cell lymphoma (MCL). All patients received cytarabine-based chemotherapeutic regimens and developed G. clavatum infection within 3 weeks from therapy initiation. In all cases, G. clavatum was isolated from central venous catheter and peripheral blood cultures. In vitro susceptibility test confirmed an intrinsic resistance to echinocandins and, in all cases, visceral localisations (spleen, liver and lung) were documented by total body computed tomography (CT) scan. A prolonged antifungal therapy with high doses liposomal amphotericin-B was necessary to obtain fever resolution. Only the patient with MCL died while the other two AML recovered, and one of them after received an allogeneic stem cell transplantation. We consecutively reviewed all published cases of infection caused by G. clavatum. Our experience and literature review indicate that G. clavatum can cause invasive infection in haematological patients, mainly in those with acute leukaemia.

DEL PRINCIPE, M.i., Sarmati, L., Cefalo, M., Fontana, C., De Santis, G., Buccisano, F., et al. (2016). A cluster of Geotrichum clavatum (Saprochaete clavata) infection in haematological patients: a first Italian report and review of literature. MYCOSES, 59(9), 594-601 [10.1111/myc.12508].

A cluster of Geotrichum clavatum (Saprochaete clavata) infection in haematological patients: a first Italian report and review of literature

DEL PRINCIPE, MARIA ILARIA;SARMATI, LOREDANA;CEFALO, MARIAGIOVANNA;FONTANA, CARLA;BUCCISANO, FRANCESCO;POSTORINO, MASSIMILIANO;SCONOCCHIA, GIUSEPPE;DEL POETA, GIOVANNI;AMADORI, SERGIO;VENDITTI, ADRIANO
2016-09

Abstract

Invasive fungal infections, usually Aspergillus and Candida, represent a major cause of morbidity and mortality in patients with malignant haematological diseases, but in the last years rare fungal infections have more frequently been reported. Here, we report the clinical history of three patients affected with haematological malignancies who developed an infection caused by Geotrichum (G.) clavatum. Two out of three patients were affected by acute myeloid leukaemia (AML), and one by mantle cell lymphoma (MCL). All patients received cytarabine-based chemotherapeutic regimens and developed G. clavatum infection within 3 weeks from therapy initiation. In all cases, G. clavatum was isolated from central venous catheter and peripheral blood cultures. In vitro susceptibility test confirmed an intrinsic resistance to echinocandins and, in all cases, visceral localisations (spleen, liver and lung) were documented by total body computed tomography (CT) scan. A prolonged antifungal therapy with high doses liposomal amphotericin-B was necessary to obtain fever resolution. Only the patient with MCL died while the other two AML recovered, and one of them after received an allogeneic stem cell transplantation. We consecutively reviewed all published cases of infection caused by G. clavatum. Our experience and literature review indicate that G. clavatum can cause invasive infection in haematological patients, mainly in those with acute leukaemia.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/06 - Oncologia Medica
English
Con Impact Factor ISI
(1→3)-β-d-glucan; Geotrichum clavatum; acute myeloid leukaemia; emerging yeast infections; fungaemia; liposomal amphotericin-B; susceptibility tests
DEL PRINCIPE, M.i., Sarmati, L., Cefalo, M., Fontana, C., De Santis, G., Buccisano, F., et al. (2016). A cluster of Geotrichum clavatum (Saprochaete clavata) infection in haematological patients: a first Italian report and review of literature. MYCOSES, 59(9), 594-601 [10.1111/myc.12508].
DEL PRINCIPE, Mi; Sarmati, L; Cefalo, M; Fontana, C; De Santis, G; Buccisano, F; Maurillo, L; De Bellis, E; Postorino, M; Sconocchia, G; DEL POETA, G; Sanguinetti, M; Amadori, S; Pagano, L; Venditti, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/173747
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