Background: We aimed to prospectively assess whether endoscopic recurrence severity at 1 year in Crohn's disease is predictive of clinical recurrence within 5 years. Methods: Clinical recurrence (Crohn's Disease Activity Index > 150) was assessed yearly for 5 years in Crohn's disease patients undergoing ileo-colonic resection. At 1 year, recurrence was assessed by colonoscopy (Rutgeerts' score ≥i1 or ≥2i) and small intestine contrast ultrasonography. Results: 40 patients were included (23 males, median age 39 [16-69] years). Clinical recurrence occurred within 5 years in 16 (40%) patients (years 1, 2, 3, 4, 5: 2 [5%]; 10 [25%]; 4 [10%]; 2 [5%]; 4 [10%], respectively). At 1 year, endoscopic recurrence (score ≥ i1) occurred in 39 (97.5%) patients (score ≥ i2: 33 [82.5%]). Ultrasound detected lesions compatible with recurrence in 39/40 (97.5%) patients. Endoscopic score at 1 year was correlated with clinical score at 2 years (p = 0.007; r = 0.41). Endoscopic score at 1 year was higher in patients with (n = 10) vs without (n = 30) clinical recurrence at 2 years (3 [2-4] vs 2 [0-4]; p = 0.003). Higher endoscopic score (>i2) at 1 year was a risk factor for clinical recurrence within 5 years (OR = 0.18; 95% CI 0.04-0.71; p = 0.008). Conclusions: In Crohn's disease, severity of endoscopic recurrence at 1 year remains a predictive marker of clinical recurrence within 5 years. Small intestine contrast ultrasonography is useful for assessing 1-year recurrence. © 2016 Editrice Gastroenterologica Italiana S.r.l.
Onali, S., Calabrese, E., Petruzziello, C., Lolli, E., Ascolani, M., Ruffa, A., et al. (2016). Post-operative recurrence of Crohn's disease: A prospective study at 5 years. DIGESTIVE AND LIVER DISEASE, 48(5), 489-494.
|Tipologia:||Articolo su rivista|
|Citazione:||Onali, S., Calabrese, E., Petruzziello, C., Lolli, E., Ascolani, M., Ruffa, A., et al. (2016). Post-operative recurrence of Crohn's disease: A prospective study at 5 years. DIGESTIVE AND LIVER DISEASE, 48(5), 489-494.|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.dld.2016.01.009|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||mag-2016|
|Titolo:||Post-operative recurrence of Crohn's disease: A prospective study at 5 years.|
|Autori:||Onali, S; Calabrese, E; Petruzziello, C; Lolli, E; Ascolani, M; Ruffa, A; Sica, G; Rossi, A; Chiaramonte, C; Pallone, F; Biancone, L|
|Appare nelle tipologie:||01 - Articolo su rivista|