Alternative splicing (AS) is a process in which precursor messenger RNA (pre-mRNA) splicing sites are differentially selected to diversify the protein isoform population. Changes in AS patterns have an essential role in normal development, differentiation and response to physiological stimuli. It is documented that AS can generate both "risk" and "protective" splice variants that can contribute to the pathogenesis of several diseases including atherosclerosis. The main endothelial receptor for oxidized low-density lipoprotein (ox-LDLs) is LOX-1 receptor protein encoded by the OLR1 gene. When OLR1 undergoes AS events, it generates three variants: OLR1, OLR1D4 and LOXIN. The latter lacks exon 5 and two-thirds of the functional domain. Literature data demonstrate a protective role of LOXIN in pathologies correlated with LOX-1 overexpression such as atherosclerosis and tumors. In this review, we summarize recent developments in understanding of OLR1 AS while also highlighting data warranting further investigation of this process as a novel therapeutic target.

Rizzacasa, B., Morini, E., Pucci, S., Murdocca, M., Novelli, G., & Amati, F. (2017). Lox-1 and its splice variants: a new challenge for atherosclerosis and cancer-targeted therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2), 290 [10.3390/ijms18020290].

Lox-1 and its splice variants: a new challenge for atherosclerosis and cancer-targeted therapies

RIZZACASA, BARBARA;PUCCI, SABINA;MURDOCCA, MICHELA;NOVELLI, GIUSEPPE;AMATI, FRANCESCA
2017

Abstract

Alternative splicing (AS) is a process in which precursor messenger RNA (pre-mRNA) splicing sites are differentially selected to diversify the protein isoform population. Changes in AS patterns have an essential role in normal development, differentiation and response to physiological stimuli. It is documented that AS can generate both "risk" and "protective" splice variants that can contribute to the pathogenesis of several diseases including atherosclerosis. The main endothelial receptor for oxidized low-density lipoprotein (ox-LDLs) is LOX-1 receptor protein encoded by the OLR1 gene. When OLR1 undergoes AS events, it generates three variants: OLR1, OLR1D4 and LOXIN. The latter lacks exon 5 and two-thirds of the functional domain. Literature data demonstrate a protective role of LOXIN in pathologies correlated with LOX-1 overexpression such as atherosclerosis and tumors. In this review, we summarize recent developments in understanding of OLR1 AS while also highlighting data warranting further investigation of this process as a novel therapeutic target.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03 - Genetica Medica
English
OLR1; alternative splicing; atherosclerosis; cancer
Rizzacasa, B., Morini, E., Pucci, S., Murdocca, M., Novelli, G., & Amati, F. (2017). Lox-1 and its splice variants: a new challenge for atherosclerosis and cancer-targeted therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18(2), 290 [10.3390/ijms18020290].
Rizzacasa, B; Morini, E; Pucci, S; Murdocca, M; Novelli, G; Amati, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/173474
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