A lab-worker was infected with HIV-1 in a biosafety level-2 of containment, without any apparent breach. Through full-genome sequencing and phylogenetic analyses, we could identify the source of infection in a replication-competent clone, unknowingly contaminating a safe experiment. Mode of transmission remains unclear. Caution is warranted when handling HIV-derived constructs.
Soria, A., Alteri, C., Scarlatti, G., Bertoli, A., Tolazzi, M., Balestra, E., et al. (2017). Occupational HIV infection in a research laboratory with unknown mode of transmission: a case report. CLINICAL INFECTIOUS DISEASES, 64(6), 3-15 [10.1093/cid/ciw851].
Occupational HIV infection in a research laboratory with unknown mode of transmission: a case report
ALTERI, CLAUDIA;BERTOLI, ADA;BALESTRA, EMANUELA;BELLOCCHI, MARIA CONCETTA;CECCHERINI SILBERSTEIN, FRANCESCA;PERNO, CARLO FEDERICO;
2017-01-01
Abstract
A lab-worker was infected with HIV-1 in a biosafety level-2 of containment, without any apparent breach. Through full-genome sequencing and phylogenetic analyses, we could identify the source of infection in a replication-competent clone, unknowingly contaminating a safe experiment. Mode of transmission remains unclear. Caution is warranted when handling HIV-derived constructs.| File | Dimensione | Formato | |
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2016_Occupational HIV infection in a research laboratory with unknown mode of transmission a case report Clin Infect Dis._soria.pdf
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