In spite of the consistent benefits for HIV-1 infected patients undergoing antiretroviral therapy, a complete immune reconstitution is usually not achieved. Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsiveness, persistent inflammatory conditions and inefficient cytotoxic T-cell response. Thymosin alpha 1 is a thymic peptide that demonstrates a peculiar ability to restore immune system homeostasis in different physiological and pathological conditions (i.e., infections, cancer, immunodeficiency, vaccination and aging) acting as multitasking protein depending on the host state of inflammation or immune dysfunction. This review reports the present knowledge on the in vitro and in vivo studies concerning the use of thymosin alpha 1 in HIV-1 infection. Recent findings and future perspectives of therapeutic intervention are discussed.

Matteucci, C., Grelli, S., Balestrieri, E., Minutolo, A., Argaw Denboba, A., Macchi, B., et al. (2017). Thymosin alpha 1 and HIV-1: Recent advances and future perspectives. FUTURE MICROBIOLOGY, 12(2), 141-155 [10.2217/fmb-2016-0125].

Thymosin alpha 1 and HIV-1: Recent advances and future perspectives

MATTEUCCI, CLAUDIA;GRELLI, SANDRO;BALESTRIERI, EMANUELA;MINUTOLO, ANTONELLA;MACCHI, BEATRICE;SINIBALDI VALLEBONA, PAOLA;PERNO, CARLO FEDERICO;MASTINO, ANTONIO;GARACI, ENRICO
2017-01-01

Abstract

In spite of the consistent benefits for HIV-1 infected patients undergoing antiretroviral therapy, a complete immune reconstitution is usually not achieved. Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsiveness, persistent inflammatory conditions and inefficient cytotoxic T-cell response. Thymosin alpha 1 is a thymic peptide that demonstrates a peculiar ability to restore immune system homeostasis in different physiological and pathological conditions (i.e., infections, cancer, immunodeficiency, vaccination and aging) acting as multitasking protein depending on the host state of inflammation or immune dysfunction. This review reports the present knowledge on the in vitro and in vivo studies concerning the use of thymosin alpha 1 in HIV-1 infection. Recent findings and future perspectives of therapeutic intervention are discussed.
2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
ART; CD8 antiviral factor; HIV; immune dysfunction; immune reconstitution
Matteucci, C., Grelli, S., Balestrieri, E., Minutolo, A., Argaw Denboba, A., Macchi, B., et al. (2017). Thymosin alpha 1 and HIV-1: Recent advances and future perspectives. FUTURE MICROBIOLOGY, 12(2), 141-155 [10.2217/fmb-2016-0125].
Matteucci, C; Grelli, S; Balestrieri, E; Minutolo, A; Argaw Denboba, A; Macchi, B; SINIBALDI VALLEBONA, P; Perno, Cf; Mastino, A; Garaci, E
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
2016_Thymosin alpha 1 and HIV1 recent advances and future perspectives_future microbiol_matteucci.pdf

solo utenti autorizzati

Licenza: Copyright dell'editore
Dimensione 1.9 MB
Formato Adobe PDF
1.9 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/173166
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 40
  • ???jsp.display-item.citation.isi??? 35
social impact