Recent studies suggest that autism spectrum disorders (ASD) result from interactions between genetic and environmental factors, whose possible links could be represented by epigenetic mechanisms. Here, we investigated the transcriptional activity of three human endogenous retrovirus (HERV) families, in peripheral blood mononuclear cells (PBMCs) from Albanian ASD children, by quantitative real-time PCR. We aimed to confirm the different expression profile already found in Italian ASD children, and to highlight any social and family health condition emerging from information gathered through a questionnaire, to be included among environmental risk factors. The presence of increased HERV-H transcriptional activity in all autistic patients could be understood as a constant epigenetic imprinting of the disease, potentially useful for early diagnosis and for the development of effective novel therapeutic strategies.

Balestrieri, E., Cipriani, C., Matteucci, C., Capodicasa, N., Pilika, A., Korca, I., et al. (2016). Transcriptional activity of human endogenous retrovirus in Albanian children with autism spectrum disorders. NEW MICROBIOLOGICA, 39(3), 228-231.

Transcriptional activity of human endogenous retrovirus in Albanian children with autism spectrum disorders

BALESTRIERI, EMANUELA;CIPRIANI, CHIARA;MATTEUCCI, CLAUDIA;SORRENTINO, ROBERTA;BUCCI, ILARIA;
2016-07-01

Abstract

Recent studies suggest that autism spectrum disorders (ASD) result from interactions between genetic and environmental factors, whose possible links could be represented by epigenetic mechanisms. Here, we investigated the transcriptional activity of three human endogenous retrovirus (HERV) families, in peripheral blood mononuclear cells (PBMCs) from Albanian ASD children, by quantitative real-time PCR. We aimed to confirm the different expression profile already found in Italian ASD children, and to highlight any social and family health condition emerging from information gathered through a questionnaire, to be included among environmental risk factors. The presence of increased HERV-H transcriptional activity in all autistic patients could be understood as a constant epigenetic imprinting of the disease, potentially useful for early diagnosis and for the development of effective novel therapeutic strategies.
lug-2016
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Autism spectrum disorders; Biological marker; Early diagnosis; Human endogenous retroviruses; PBMCs
Balestrieri, E., Cipriani, C., Matteucci, C., Capodicasa, N., Pilika, A., Korca, I., et al. (2016). Transcriptional activity of human endogenous retrovirus in Albanian children with autism spectrum disorders. NEW MICROBIOLOGICA, 39(3), 228-231.
Balestrieri, E; Cipriani, C; Matteucci, C; Capodicasa, N; Pilika, A; Korca, I; Sorrentino, R; Argaw Denboba, A; Bucci, I; Miele, M; Coniglio, A; Alessandrelli, R; Vallebona, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/173164
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