Sarcopenia, osteoporosis and osteoarthritis are the most frequent musculoskeletal disorders affecting older people. The main aim of this study was to test the hypothesis that the balance between BMPs and myostatin pathways regulates the age-related muscle degeneration in OP and OA patients. To this end, we investigated the relationship among the expression of BMP-2/4-7, myostatin and phosphorylated Smads1-5-8 and the muscle quality, evaluated in term of fibers atrophy and satellite cells activity.
Scimeca, M., Piccirilli, E., Mastrangeli, F., Rao, C., Feola, M., Orlandi, A., et al. (2017). Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia. JOURNAL OF TRANSLATIONAL MEDICINE, 15(1), 34 [10.1186/s12967-017-1143-6].
Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia
SCIMECA, MANUEL;MASTRANGELI, FRANCESCA;FEOLA, MAURIZIO;ORLANDI, AUGUSTO;GASBARRA, ELENA;BONANNO, ELENA;TARANTINO, UMBERTO
2017-02-15
Abstract
Sarcopenia, osteoporosis and osteoarthritis are the most frequent musculoskeletal disorders affecting older people. The main aim of this study was to test the hypothesis that the balance between BMPs and myostatin pathways regulates the age-related muscle degeneration in OP and OA patients. To this end, we investigated the relationship among the expression of BMP-2/4-7, myostatin and phosphorylated Smads1-5-8 and the muscle quality, evaluated in term of fibers atrophy and satellite cells activity.| File | Dimensione | Formato | |
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