This study concerns the role of apoptosis in the growth of human neuroblastomas transplanted into immunodeficient SCID mice. Human neuroblastoma cell lines may consist of one or more distinct phenotypes including the neural 'N-type' and flat substrate-adherent 'S-type'. A differential phenotype-specific proliferation was apparent among S- and N-type cell clones transplanted into SCID mice when compared with the wild-type SK-N-BE(2) cell line. This differential growth capacity of the tumours was correlated with spontaneous apoptosis. Another SK-N-BE(2)-derived cell line (TGA), displaying high levels of apoptosis upon stable transfection with the full length 'tissue' transglutaminase (tTG) cDNA, was unable to induce tumour development when xenografted into SCID mice. To support these observations, the expression of apoptosis-related genes (i.e., bcl-2, p53, and tTG) in the various neuroblastomas was also investigated.

Piacentini, M., Piredda, L., Starace, D., Annicchiarico Petruzzelli, M., Mattei, M., Oliverio, S., et al. (1996). Differential growth of N- and S-type human neuroblastoma cells xenografted into SCID mice. Correlation with apoptosis. JOURNAL OF PATHOLOGY, 180(4), 415-422 [10.1002/(SICI)1096-9896(199612)180:4<415::AID-PATH684>3.0.CO;2-A].

Differential growth of N- and S-type human neuroblastoma cells xenografted into SCID mice. Correlation with apoptosis

PIACENTINI, MAURO;PIREDDA, LUCIA;MATTEI, MAURIZIO;OLIVERIO, SERAFINA;FARRACE, MARIA GRAZIA;MELINO, GENNARO
1996-01-01

Abstract

This study concerns the role of apoptosis in the growth of human neuroblastomas transplanted into immunodeficient SCID mice. Human neuroblastoma cell lines may consist of one or more distinct phenotypes including the neural 'N-type' and flat substrate-adherent 'S-type'. A differential phenotype-specific proliferation was apparent among S- and N-type cell clones transplanted into SCID mice when compared with the wild-type SK-N-BE(2) cell line. This differential growth capacity of the tumours was correlated with spontaneous apoptosis. Another SK-N-BE(2)-derived cell line (TGA), displaying high levels of apoptosis upon stable transfection with the full length 'tissue' transglutaminase (tTG) cDNA, was unable to induce tumour development when xenografted into SCID mice. To support these observations, the expression of apoptosis-related genes (i.e., bcl-2, p53, and tTG) in the various neuroblastomas was also investigated.
1996
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04 - PATOLOGIA GENERALE
English
Piacentini, M., Piredda, L., Starace, D., Annicchiarico Petruzzelli, M., Mattei, M., Oliverio, S., et al. (1996). Differential growth of N- and S-type human neuroblastoma cells xenografted into SCID mice. Correlation with apoptosis. JOURNAL OF PATHOLOGY, 180(4), 415-422 [10.1002/(SICI)1096-9896(199612)180:4<415::AID-PATH684>3.0.CO;2-A].
Piacentini, M; Piredda, L; Starace, D; Annicchiarico Petruzzelli, M; Mattei, M; Oliverio, S; Farrace, Mg; Melino, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/172016
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