Somatostatin analogs (SSAs), which were initially used to control hormonal syndromes associated with neuroendocrine neoplasms (NENs), have been successfully proposed as antiproliferative agents, able to control tumor growth in patients affected by gastroenteropancreatic (GEP)-NENs. The development of long-acting formulations of SSAs which require only weekly or monthly injections can improve patient compliance. In particular, lanreotide (LAN) Autogel(®), which is a viscous aqueous formulation supplied in ready-to-use prefilled syringes, can be administered every 28-56 days. Since its introduction in the clinical practice, several studies evaluated the clinical utility of LAN Autogel in the medical treatment of GEP-NENs. Although there is no evidence of an overall survival benefit, these studies confirm the efficacy of LAN Autogel in terms of benefit in progression-free survival, and in more than half of cases, a reduction of tumor markers can be observed during treatment with this drug. Moreover, LAN Autogel is widely recognized to be effective in controlling tumor-related symptoms in the majority of patients affected by GEP tumors, especially in patients affected by carcinoid syndrome, improving considerably patients' quality of life.

Paragliola, R.m., Prete, A., Papi, G., Torino, F., Corsello, A., Pontecorvi, A., et al. (2016). Clinical utility of lanreotide autogel® in gastroenteropancreatic neuroendocrine tumors. DRUG DESIGN, DEVELOPMENT AND THERAPY, 10, 3459-3470 [10.2147/DDDT.S76732].

Clinical utility of lanreotide autogel® in gastroenteropancreatic neuroendocrine tumors

TORINO, FRANCESCO;
2016

Abstract

Somatostatin analogs (SSAs), which were initially used to control hormonal syndromes associated with neuroendocrine neoplasms (NENs), have been successfully proposed as antiproliferative agents, able to control tumor growth in patients affected by gastroenteropancreatic (GEP)-NENs. The development of long-acting formulations of SSAs which require only weekly or monthly injections can improve patient compliance. In particular, lanreotide (LAN) Autogel(®), which is a viscous aqueous formulation supplied in ready-to-use prefilled syringes, can be administered every 28-56 days. Since its introduction in the clinical practice, several studies evaluated the clinical utility of LAN Autogel in the medical treatment of GEP-NENs. Although there is no evidence of an overall survival benefit, these studies confirm the efficacy of LAN Autogel in terms of benefit in progression-free survival, and in more than half of cases, a reduction of tumor markers can be observed during treatment with this drug. Moreover, LAN Autogel is widely recognized to be effective in controlling tumor-related symptoms in the majority of patients affected by GEP tumors, especially in patients affected by carcinoid syndrome, improving considerably patients' quality of life.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/06 - Oncologia Medica
English
Con Impact Factor ISI
gastroentero-pancreatic neuroendocrine neoplasms; gastroenteropancreatic neuroendocrine tumors; lanreotide Autogel; somatostatin analogs
Paragliola, R.m., Prete, A., Papi, G., Torino, F., Corsello, A., Pontecorvi, A., et al. (2016). Clinical utility of lanreotide autogel® in gastroenteropancreatic neuroendocrine tumors. DRUG DESIGN, DEVELOPMENT AND THERAPY, 10, 3459-3470 [10.2147/DDDT.S76732].
Paragliola, R; Prete, A; Papi, G; Torino, F; Corsello, A; Pontecorvi, A; Corsello, S
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Paragliola et al. DrugDesDevTher2016.pdf

accesso aperto

Licenza: Non specificato
Dimensione 559.51 kB
Formato Adobe PDF
559.51 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/171358
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact