Response to seasonal influenza vaccination is currently evaluated by antibody correlates that estimate vaccine seroconversion as well as immune protection. These correlates rely on the general dogmas surrounding seasonal influenza vaccination; that is, that vaccine-induced antibodies would exclusively generate immunity to influenza vaccine strains and that protective immunity would wane before the next season. Here, we summarize recently reported data on immunity to seasonal influenza in healthy individuals and rediscuss results on yearly vaccinated pediatric immunocompromised patients that together highlight the need for revision of the current correlates of vaccine response to shift from quantitative to qualitative measurements.

Cagigi, A., Cotugno, N., Rinaldi, S., Santilli, V., Rossi, P., & Palma, P. (2016). Downfall of the current antibody correlates of influenza vaccine response in yearly vaccinated subjects: Toward qualitative rather than quantitative assays. PEDIATRIC ALLERGY AND IMMUNOLOGY, 27(1), 22-27 [10.1111/pai.12483].

Downfall of the current antibody correlates of influenza vaccine response in yearly vaccinated subjects: Toward qualitative rather than quantitative assays

Cotugno, N;RINALDI, STEFANO;ROSSI, PAOLO;PALMA, PAOLO
2016

Abstract

Response to seasonal influenza vaccination is currently evaluated by antibody correlates that estimate vaccine seroconversion as well as immune protection. These correlates rely on the general dogmas surrounding seasonal influenza vaccination; that is, that vaccine-induced antibodies would exclusively generate immunity to influenza vaccine strains and that protective immunity would wane before the next season. Here, we summarize recently reported data on immunity to seasonal influenza in healthy individuals and rediscuss results on yearly vaccinated pediatric immunocompromised patients that together highlight the need for revision of the current correlates of vaccine response to shift from quantitative to qualitative measurements.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/38 - Pediatria Generale e Specialistica
English
Con Impact Factor ISI
antibody vs. memory B-cell responses; long-lasting immunologic memory; repeated immunization; Antibodies, Viral; Biomarkers; Humans; Immunocompromised Host; Influenza A virus; Influenza Vaccines; Influenza, Human; Predictive Value of Tests; Reproducibility of Results; Seasons; Time Factors; Treatment Outcome; Immunization Schedule; Serologic Tests; Vaccination
Cagigi, A., Cotugno, N., Rinaldi, S., Santilli, V., Rossi, P., & Palma, P. (2016). Downfall of the current antibody correlates of influenza vaccine response in yearly vaccinated subjects: Toward qualitative rather than quantitative assays. PEDIATRIC ALLERGY AND IMMUNOLOGY, 27(1), 22-27 [10.1111/pai.12483].
Cagigi, A; Cotugno, N; Rinaldi, S; Santilli, V; Rossi, P; Palma, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/171255
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