Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), the primary receptor for ox-LDL in endothelial cells, is a multi-ligand scavenger receptor that plays a crucial role in the pathogenesis of atherosclerosis and cardiovascular disorders and recently identified as a tumor marker. LOX-1 is naturally present in caveolae/lipid rafts in plasma membranes and disruption of these membrane domains by cholesterol-lowering drugs leads to a spatial disorganization of LOX-1 and a marked loss of specific LOX-1 function in terms of ox-LDL binding and internalization. Moreover, cholesterol depletion triggers the release of LOX-1 in exosomes and enhances shedding of LOX-1 ectodomain. We here provide an overview of the involvement of membrane and circulating cholesterol in LOX-1 function and shedding and its impact on cardiovascular pathologies and cancer. In particular, we consider the available biological and molecular evidence indicating LOX-1 as a potential therapeutic target for atherosclerosis, inflammation processes, myocardial infarction and cholesterol-lowering drugs as specific inhibitors of LOX-1 function.

Raniolo, S., Vindigni, G., Biocca, S. (2016). Cholesterol level regulates lectin-like oxidized low-density lipoprotein receptor-1 function. BIOMEDICAL SPECTROSCOPY AND IMAGING, 5(1), 87-99 [10.3233/BSI-160156].

Cholesterol level regulates lectin-like oxidized low-density lipoprotein receptor-1 function

RANIOLO, SOFIA;VINDIGNI, GIULIA;Biocca, S.
2016

Abstract

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), the primary receptor for ox-LDL in endothelial cells, is a multi-ligand scavenger receptor that plays a crucial role in the pathogenesis of atherosclerosis and cardiovascular disorders and recently identified as a tumor marker. LOX-1 is naturally present in caveolae/lipid rafts in plasma membranes and disruption of these membrane domains by cholesterol-lowering drugs leads to a spatial disorganization of LOX-1 and a marked loss of specific LOX-1 function in terms of ox-LDL binding and internalization. Moreover, cholesterol depletion triggers the release of LOX-1 in exosomes and enhances shedding of LOX-1 ectodomain. We here provide an overview of the involvement of membrane and circulating cholesterol in LOX-1 function and shedding and its impact on cardiovascular pathologies and cancer. In particular, we consider the available biological and molecular evidence indicating LOX-1 as a potential therapeutic target for atherosclerosis, inflammation processes, myocardial infarction and cholesterol-lowering drugs as specific inhibitors of LOX-1 function.
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Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/12
English
Senza Impact Factor ISI
cholesterol; LOX-1 receptor; ox-LDL; lipid rafts; MCD; statins.
Raniolo, S., Vindigni, G., Biocca, S. (2016). Cholesterol level regulates lectin-like oxidized low-density lipoprotein receptor-1 function. BIOMEDICAL SPECTROSCOPY AND IMAGING, 5(1), 87-99 [10.3233/BSI-160156].
Raniolo, S; Vindigni, G; Biocca, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/171204
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