To avoid overdiagnosis, accuracy in the identification of true malaria cases is of critical importance. Samples (either whole blood, dried blood spots or plasma/serum) collected at the time of clinically diagnosed malaria episodes in a cohort of Malawian HIV-infected mothers and their children were retrospectively tested with the enzyme-linked immunosorbent assay (ELISA) for HRP-2 (histidine-rich protein 2) detection. There were 55 and 56 clinically diagnosed cases of malaria in mothers and children, respectively, with samples available for testing. Rates of laboratory-confirmed episodes were 20% (11 of 55) in mothers and 16.1% (9 of 56) in children. Hemoglobin was lower in children with confirmed malaria compared to those with clinical malaria diagnosis. The results of our study support the widespread use of rapid diagnostic tests.

Giuliano, M., Galluzzo, C., Mancinelli, S., Andreotti, M., Jere, H., Sagno, J., et al. (2015). Laboratory confirmation of clinically diagnosed malaria in a cohort of HIV-infected mothers and their children in Malawi. JOURNAL OF TROPICAL PEDIATRICS, 61(3), 222-225 [10.1093/tropej/fmv011].

Laboratory confirmation of clinically diagnosed malaria in a cohort of HIV-infected mothers and their children in Malawi

MANCINELLI, SANDRO;ERBA, FULVIO;BUONOMO, ERSILIA;SCARCELLA, PAOLA;PALOMBI, LEONARDO
2015-01-01

Abstract

To avoid overdiagnosis, accuracy in the identification of true malaria cases is of critical importance. Samples (either whole blood, dried blood spots or plasma/serum) collected at the time of clinically diagnosed malaria episodes in a cohort of Malawian HIV-infected mothers and their children were retrospectively tested with the enzyme-linked immunosorbent assay (ELISA) for HRP-2 (histidine-rich protein 2) detection. There were 55 and 56 clinically diagnosed cases of malaria in mothers and children, respectively, with samples available for testing. Rates of laboratory-confirmed episodes were 20% (11 of 55) in mothers and 16.1% (9 of 56) in children. Hemoglobin was lower in children with confirmed malaria compared to those with clinical malaria diagnosis. The results of our study support the widespread use of rapid diagnostic tests.
2015
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/42 - IGIENE GENERALE E APPLICATA
Settore MED/17 - MALATTIE INFETTIVE
English
Con Impact Factor ISI
HIV; Malawi; diagnosis; malaria; Adult; Animals; Antigens, Protozoan; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections; HIV-1; Humans; Malaria; Male; Mothers; Plasmodium; Pregnancy; Pregnancy Complications; Proteins; Retrospective Studies
Giuliano, M., Galluzzo, C., Mancinelli, S., Andreotti, M., Jere, H., Sagno, J., et al. (2015). Laboratory confirmation of clinically diagnosed malaria in a cohort of HIV-infected mothers and their children in Malawi. JOURNAL OF TROPICAL PEDIATRICS, 61(3), 222-225 [10.1093/tropej/fmv011].
Giuliano, M; Galluzzo, C; Mancinelli, S; Andreotti, M; Jere, H; Sagno, J; Maulidi, M; Erba, F; Amici, R; Buonomo, E; Scarcella, P; Marazzi, M; Vella, ...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/170994
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