Findings on brain structural abnormalities in patients with bipolar disorder (BP) are inconsistent and little is known about age-related evolution of these changes. We employed a cross-sectional, case-control study to compare structural age-related brain trajectories in patients with BP and healthy control subjects (HC) over a period of approximately 50 years. The primary aim was to understand whether white (WM) and gray matter (GM) abnormalities are present from the beginning of the illness and how they change over time.

Sani, G., Chiapponi, C., Piras, F., Ambrosi, E., Simonetti, A., Danese, E., et al. (2016). Gray and white matter trajectories in patients with bipolar disorder. BIPOLAR DISORDERS, 18(1), 52-62 [10.1111/bdi.12359].

Gray and white matter trajectories in patients with bipolar disorder

CALTAGIRONE, CARLO;
2016

Abstract

Findings on brain structural abnormalities in patients with bipolar disorder (BP) are inconsistent and little is known about age-related evolution of these changes. We employed a cross-sectional, case-control study to compare structural age-related brain trajectories in patients with BP and healthy control subjects (HC) over a period of approximately 50 years. The primary aim was to understand whether white (WM) and gray matter (GM) abnormalities are present from the beginning of the illness and how they change over time.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - Neurologia
English
Con Impact Factor ISI
bipolar disorder; brain alterations; cerebellum; posterior cingulate cortex; posterior limb of the internal capsule; thalamus; voxel-based morphometry; Adult; Age Factors; Atrophy; Bipolar Disorder; Brain; Case-Control Studies; Cerebellum; Cross-Sectional Studies; Female; Gray Matter; Gyrus Cinguli; Humans; Internal Capsule; Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Thalamus; White Matter
Sani, G., Chiapponi, C., Piras, F., Ambrosi, E., Simonetti, A., Danese, E., et al. (2016). Gray and white matter trajectories in patients with bipolar disorder. BIPOLAR DISORDERS, 18(1), 52-62 [10.1111/bdi.12359].
Sani, G; Chiapponi, C; Piras, F; Ambrosi, E; Simonetti, A; Danese, E; Janiri, D; Brugnoli, R; De Filippis, S; Caltagirone, C; Girardi, P; Spalletta, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/170868
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