Patients with Scans-Without-Evidence-of-Dopaminergic-Deficit (SWEDD) often present asymmetric rest tremor not responsive to levodopa. Although a dystonic origin of this tremor has been proposed, the underlying pathophysiology of such condition is still unclear. An abnormal activity in the Cerebello-Thalamo-Cortical circuit is involved in the pathogenesis of tremor and other movement disorders. Here we used different paradigms of cerebellar transcranial magnetic stimulation to evaluate the Cerebello-Thalamo-Cortical functioning in patients with normal scans.
Schirinzi, T., Di Lorenzo, F., Ponzo, V., Palmieri, M., Bentivoglio, A., Schillaci, O., et al. (2016). Mild cerebello-thalamo-cortical impairment in patients with normal dopaminergic scans (SWEDD). PARKINSONISM & RELATED DISORDERS, 28, 23-28 [10.1016/j.parkreldis.2016.03.023].
Mild cerebello-thalamo-cortical impairment in patients with normal dopaminergic scans (SWEDD)
SCHIRINZI, TOMMASO;SCHILLACI, ORAZIO;PISANI, ANTONIO;
2016-01-01
Abstract
Patients with Scans-Without-Evidence-of-Dopaminergic-Deficit (SWEDD) often present asymmetric rest tremor not responsive to levodopa. Although a dystonic origin of this tremor has been proposed, the underlying pathophysiology of such condition is still unclear. An abnormal activity in the Cerebello-Thalamo-Cortical circuit is involved in the pathogenesis of tremor and other movement disorders. Here we used different paradigms of cerebellar transcranial magnetic stimulation to evaluate the Cerebello-Thalamo-Cortical functioning in patients with normal scans.| File | Dimensione | Formato | |
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