Recent clinical and preclinical studies have shown that hyperkinetic disorders such as Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are all characterized by loss of the ability to reverse synaptic plasticity and an associated increase in the excitability of excitatory neuronal inputs to a range of cortical and subcortical brain areas. Moreover, these changes have been detected in humans with hyperkinetic disorders either via direct recordings from implanted deep brain electrodes or noninvasively using transcranial magnetic stimulation. Here we discuss the mechanisms underlying the loss of bidirectional plasticity and the possibility that future interventions could be devised to reverse these changes in patients with hyperkinetic movement disorders.

Calabresi, P., Pisani, A., Rothwell, J., Ghiglieri, V., Obeso, J., & Picconi, B. (2016). Hyperkinetic disorders and loss of synaptic downscaling. NATURE NEUROSCIENCE, 19(7), 868-875 [10.1038/nn.4306].

Hyperkinetic disorders and loss of synaptic downscaling

CALABRESI, PAOLO;PISANI, ANTONIO;GHIGLIERI, VERONICA;PICCONI, BARBARA
2016

Abstract

Recent clinical and preclinical studies have shown that hyperkinetic disorders such as Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are all characterized by loss of the ability to reverse synaptic plasticity and an associated increase in the excitability of excitatory neuronal inputs to a range of cortical and subcortical brain areas. Moreover, these changes have been detected in humans with hyperkinetic disorders either via direct recordings from implanted deep brain electrodes or noninvasively using transcranial magnetic stimulation. Here we discuss the mechanisms underlying the loss of bidirectional plasticity and the possibility that future interventions could be devised to reverse these changes in patients with hyperkinetic movement disorders.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - Neurologia
English
Con Impact Factor ISI
Calabresi, P., Pisani, A., Rothwell, J., Ghiglieri, V., Obeso, J., & Picconi, B. (2016). Hyperkinetic disorders and loss of synaptic downscaling. NATURE NEUROSCIENCE, 19(7), 868-875 [10.1038/nn.4306].
Calabresi, P; Pisani, A; Rothwell, J; Ghiglieri, V; Obeso, J; Picconi, B
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/168923
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