An experimental model of microsurgical carotid endarterectomy in rats developed recently in our laboratory was used in the present study. Our adult Sprague-Dawley rats were killed by in vivo perfusion-fixation at 5 minutes, 15 minutes, 30 minutes, 3 hours, 1 day, and 3 days after the completion of carotid endarterectomy, and vessels were studied by scanning electron microscopy, light microscopy, and transmission electron microscopy for evaluation of thrombotic changes at the level of arterial injury. Although no postoperative carotid occlusion was observed, thrombus formation was noted as early as 15 minutes after recirculation. Thrombus formation reached its peak at 3 hours and was no longer detected 3 days after the procedure. Microsurgical carotid endarterectomy in rats may be a useful experimental model for the evaluation of antithrombotic drugs.

Spallone, A., Sasaki, T., Kassel, N. (1985). Time course of thrombotic changes after microsurgical carotid endarterectomy in the rat. NEUROSURGERY, 16(6), 773-779.

Time course of thrombotic changes after microsurgical carotid endarterectomy in the rat

SPALLONE, ALDO;
1985

Abstract

An experimental model of microsurgical carotid endarterectomy in rats developed recently in our laboratory was used in the present study. Our adult Sprague-Dawley rats were killed by in vivo perfusion-fixation at 5 minutes, 15 minutes, 30 minutes, 3 hours, 1 day, and 3 days after the completion of carotid endarterectomy, and vessels were studied by scanning electron microscopy, light microscopy, and transmission electron microscopy for evaluation of thrombotic changes at the level of arterial injury. Although no postoperative carotid occlusion was observed, thrombus formation was noted as early as 15 minutes after recirculation. Thrombus formation reached its peak at 3 hours and was no longer detected 3 days after the procedure. Microsurgical carotid endarterectomy in rats may be a useful experimental model for the evaluation of antithrombotic drugs.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/27 - Neurochirurgia
English
Con Impact Factor ISI
Spallone, A., Sasaki, T., Kassel, N. (1985). Time course of thrombotic changes after microsurgical carotid endarterectomy in the rat. NEUROSURGERY, 16(6), 773-779.
Spallone, A; Sasaki, T; Kassel, N
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/167750
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 5
  • ???jsp.display-item.citation.isi??? ND
social impact