Diabetic polyneuropathy and cardiovascular autonomic neuropathy are common and disabling complications of diabetes. Although glycaemic control and cardiovascular risk factors are major contributory elements in its development, diabetic neuropathy recognizes a multifactorial influence and a multiplicity of pathogenetic mechanisms. Thus genetic and environmental factors may contribute to its susceptibility, each with a modest contribution, by targeting various metabolic and microvascular pathways whose alterations intervene in diabetic neuropathy pathogenesis. This review is aimed at describing major data from the available literature regarding genetic susceptibility to diabetic neuropathies. It provides an overview of the genes reported as associated with the development or progression of these complications, i.e. ACE, MTHFR, GST, GLO1, APOE, TCF7L2, VEGF, IL-4, GPX1, eNOS, ADRA2B, GFRA2, MIR146A, MIR128A. The identification of genetic susceptibility can help in both expanding the comprehension of the pathogenetic mechanisms of diabetic nerve damage and identifying biomarkers of risk prediction and response to therapeutic intervention.

Politi, C., Ciccacci, C., D'Amato, C., Novelli, G., Borgiani, P., & Spallone, V. (2016). Recent advances in exploring the genetic susceptibility to diabetic neuropathy. DIABETES RESEARCH AND CLINICAL PRACTICE, 120, 198-208 [10.1016/j.diabres.2016.08.006].

Recent advances in exploring the genetic susceptibility to diabetic neuropathy

CICCACCI, CINZIA;D'AMATO, CINZIA;NOVELLI, GIUSEPPE;BORGIANI, PAOLA;SPALLONE, VINCENZA
2016-08-26

Abstract

Diabetic polyneuropathy and cardiovascular autonomic neuropathy are common and disabling complications of diabetes. Although glycaemic control and cardiovascular risk factors are major contributory elements in its development, diabetic neuropathy recognizes a multifactorial influence and a multiplicity of pathogenetic mechanisms. Thus genetic and environmental factors may contribute to its susceptibility, each with a modest contribution, by targeting various metabolic and microvascular pathways whose alterations intervene in diabetic neuropathy pathogenesis. This review is aimed at describing major data from the available literature regarding genetic susceptibility to diabetic neuropathies. It provides an overview of the genes reported as associated with the development or progression of these complications, i.e. ACE, MTHFR, GST, GLO1, APOE, TCF7L2, VEGF, IL-4, GPX1, eNOS, ADRA2B, GFRA2, MIR146A, MIR128A. The identification of genetic susceptibility can help in both expanding the comprehension of the pathogenetic mechanisms of diabetic nerve damage and identifying biomarkers of risk prediction and response to therapeutic intervention.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - Endocrinologia
Settore MED/03 - Genetica Medica
eng
Con Impact Factor ISI
Diabetic polyneuropathy Cardiovascular autonomic neuropathy Genetic susceptibility Polymorphisms Genomic biomarkers
This study was supported by grants from Fondazione Roma 2013.
Politi, C., Ciccacci, C., D'Amato, C., Novelli, G., Borgiani, P., & Spallone, V. (2016). Recent advances in exploring the genetic susceptibility to diabetic neuropathy. DIABETES RESEARCH AND CLINICAL PRACTICE, 120, 198-208 [10.1016/j.diabres.2016.08.006].
Politi, C; Ciccacci, C; D'Amato, C; Novelli, G; Borgiani, P; Spallone, V
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/166701
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