The genomic 3' structure of the gene coding for the human slow skeletal troponin T (TNNT1) gene, is reported. An intron of 912 nucleotides containing an Alu-element has been identified and characterized. The complexity of the sequenced region suggests an alternative exon use. The present results may be valuable for further studies on the gene structure of TNNT1 and the related troponin gene family.

Novelli, G., Gennarelli, M., Sangiuolo, F.C., D'Agruma, L., Cicero, S.l., Melchionda, S., et al. (1993). Isolation and cloning by a polymerase chain reaction of a genomic DNA fragment of the human slow skeletal troponin (TNNT1) gene. CELL BIOCHEMISTRY AND FUNCTION, 11(3), 187-191 [10.1002/cbf.290110306].

Isolation and cloning by a polymerase chain reaction of a genomic DNA fragment of the human slow skeletal troponin (TNNT1) gene

NOVELLI, GIUSEPPE;SANGIUOLO, FEDERICA CARLA;
1993

Abstract

The genomic 3' structure of the gene coding for the human slow skeletal troponin T (TNNT1) gene, is reported. An intron of 912 nucleotides containing an Alu-element has been identified and characterized. The complexity of the sequenced region suggests an alternative exon use. The present results may be valuable for further studies on the gene structure of TNNT1 and the related troponin gene family.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03 - Genetica Medica
English
Base Sequence; Chromosomes, Human, Pair 19; Cloning, Molecular; Genomic Library; Humans; Introns; Molecular Sequence Data; Multigene Family; Polymerase Chain Reaction; Repetitive Sequences, Nucleic Acid; Sequence Analysis, DNA; Troponin; Troponin T
Novelli, G., Gennarelli, M., Sangiuolo, F.C., D'Agruma, L., Cicero, S.l., Melchionda, S., et al. (1993). Isolation and cloning by a polymerase chain reaction of a genomic DNA fragment of the human slow skeletal troponin (TNNT1) gene. CELL BIOCHEMISTRY AND FUNCTION, 11(3), 187-191 [10.1002/cbf.290110306].
Novelli, G; Gennarelli, M; Sangiuolo, Fc; D'Agruma, L; Cicero, S; Melchionda, S; Dallapiccola, B
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/166543
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