We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.

Margiotti, K., Sangiuolo, F.C., De Luca, A., Froio, F., Pearce, C.l., Ricci-Barbini, V., et al. (2000). Evidence for an association between the SRD5A2 (type II steroid 5 alpha-reductase) locus and prostate cancer in Italian patients. DISEASE MARKERS, 16(3-4), 147-150.

Evidence for an association between the SRD5A2 (type II steroid 5 alpha-reductase) locus and prostate cancer in Italian patients

SANGIUOLO, FEDERICA CARLA;MICALI, FRANCESCO;NOVELLI, GIUSEPPE;
2000

Abstract

We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/03 - Genetica Medica
English
Con Impact Factor ISI
3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adenocarcinoma; Aged; Aged, 80 and over; Amino Acid Substitution; Androstane-3,17-diol; Codon; Dinucleotide Repeats; Ethnic Groups; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genotype; Humans; Italy; Male; Middle Aged; Mutation, Missense; Neoplasm Proteins; Polymorphism, Genetic; Prostatic Neoplasms; Risk
Margiotti, K., Sangiuolo, F.C., De Luca, A., Froio, F., Pearce, C.l., Ricci-Barbini, V., et al. (2000). Evidence for an association between the SRD5A2 (type II steroid 5 alpha-reductase) locus and prostate cancer in Italian patients. DISEASE MARKERS, 16(3-4), 147-150.
Margiotti, K; Sangiuolo, Fc; De Luca, A; Froio, F; Pearce, C; Ricci Barbini, V; Micali, F; Bonafe, M; Franceschi, C; Dallapiccola, B; Novelli, G; Reichardt, J
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/166510
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 36
social impact