Mood disorders, including anxiety and depression, are frequently diagnosed in multiple sclerosis (MS) patients, even independently of the disabling symptoms associated with the disease. Anatomical, biochemical, and pharmacological evidence indicates that type-1 cannabinoid receptor (CB1R) is implicated in the control of emotional behavior and is modulated during inflammatory neurodegenerative diseases such as MS and experimental autoimmune encephalomyelitis (EAE).
Gentile, A., Fresegna, D., Musella, A., Sepman, H., Bullitta, S., De Vito, F., et al. (2016). Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis. JOURNAL OF NEUROINFLAMMATION, 13(1), 231-231 [10.1186/s12974-016-0682-8].
Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis
GENTILE, ANTONIETTA;FRESEGNA, DIEGO;MUSELLA, ALESSANDRA;SEPMAN, HELENA;BULLITTA, SILVIA;MACCARRONE, MAURO;MERCURI, NICOLA BIAGIO;CENTONZE, DIEGO
2016-09-02
Abstract
Mood disorders, including anxiety and depression, are frequently diagnosed in multiple sclerosis (MS) patients, even independently of the disabling symptoms associated with the disease. Anatomical, biochemical, and pharmacological evidence indicates that type-1 cannabinoid receptor (CB1R) is implicated in the control of emotional behavior and is modulated during inflammatory neurodegenerative diseases such as MS and experimental autoimmune encephalomyelitis (EAE).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
