Compulsive symptoms develop in patients exposed to pramipexole (PPX), a dopaminergic agonist with high selectivity for the D3 receptor. Consistently, we demonstrated that PPX produces an exaggerated increase in contrafreeloading (CFL) for water, a repetitive and highly inflexible behavior that models core aspects of compulsive disorders.

Schepisi, C., Pignataro, A., Doronzio, S., Piccinin, S., Ferraina, C., Di Prisco, S., et al. (2016). Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole. PSYCHOPHARMACOLOGY, 233, 727-737 [10.1007/s00213-015-4150-4].

Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole

MERCURI, NICOLA BIAGIO;NISTICO', ROBERT GIOVANNI;
2016

Abstract

Compulsive symptoms develop in patients exposed to pramipexole (PPX), a dopaminergic agonist with high selectivity for the D3 receptor. Consistently, we demonstrated that PPX produces an exaggerated increase in contrafreeloading (CFL) for water, a repetitive and highly inflexible behavior that models core aspects of compulsive disorders.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14
English
Con Impact Factor ISI
Contrafreeloading; D3 receptor; Hippocampus; Obsessive-compulsive disorder; Pramipexole
Schepisi, C., Pignataro, A., Doronzio, S., Piccinin, S., Ferraina, C., Di Prisco, S., et al. (2016). Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole. PSYCHOPHARMACOLOGY, 233, 727-737 [10.1007/s00213-015-4150-4].
Schepisi, C; Pignataro, A; Doronzio, S; Piccinin, S; Ferraina, C; Di Prisco, S; Feligioni, M; Pittaluga, A; Mercuri, Nb; Ammassari Teule, M; Nistico', Rg; Nencini, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/165634
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