Compulsive symptoms develop in patients exposed to pramipexole (PPX), a dopaminergic agonist with high selectivity for the D3 receptor. Consistently, we demonstrated that PPX produces an exaggerated increase in contrafreeloading (CFL) for water, a repetitive and highly inflexible behavior that models core aspects of compulsive disorders.
Schepisi, C., Pignataro, A., Doronzio, S., Piccinin, S., Ferraina, C., Di Prisco, S., et al. (2016). Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole. PSYCHOPHARMACOLOGY, 233, 727-737 [10.1007/s00213-015-4150-4].
Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole
MERCURI, NICOLA BIAGIO;NISTICO', ROBERT GIOVANNI;
2016-02-01
Abstract
Compulsive symptoms develop in patients exposed to pramipexole (PPX), a dopaminergic agonist with high selectivity for the D3 receptor. Consistently, we demonstrated that PPX produces an exaggerated increase in contrafreeloading (CFL) for water, a repetitive and highly inflexible behavior that models core aspects of compulsive disorders.| File | Dimensione | Formato | |
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