Objective: To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis. Methods: Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and semiquantitative polymerase chain reaction. Results: The study included biopsies from nine patients with psoriatic arthritis and nine control subjects. S100A8 and S100A9 were present at visibly higher levels in psoriatic plaques compared with normal skin samples. S100A8 and S100A9 RNA levels were significantly higher in the peripheral region of plaques compared with the central region. Conclusion: Both S100A8 and S100A9 may represent good therapeutic targets in psoriasis and psoriatic arthritis.

Chimenti, M.S., Triggianese, P., Botti, E., Narcisi, A., Conigliaro, P., Giunta, A., et al. (2016). S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 44(1_suppl), 33-37 [10.1177/0300060515598900].

S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis

CHIMENTI, MARIA SOLE;TRIGGIANESE, PAOLA;Botti, E;CONIGLIARO, PAOLA;GIUNTA, ALESSANDRO;PERRICONE, ROBERTO;
2016

Abstract

Objective: To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis. Methods: Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and semiquantitative polymerase chain reaction. Results: The study included biopsies from nine patients with psoriatic arthritis and nine control subjects. S100A8 and S100A9 were present at visibly higher levels in psoriatic plaques compared with normal skin samples. S100A8 and S100A9 RNA levels were significantly higher in the peripheral region of plaques compared with the central region. Conclusion: Both S100A8 and S100A9 may represent good therapeutic targets in psoriasis and psoriatic arthritis.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/16 - Reumatologia
English
Inflammation; psoriatic arthritis; psoriatic plaques; S100A8; S100A9; skin lesions; Medicine (all); Biochemistry; Cell Biology; Biochemistry (medical)
http://imr.sagepub.com/content/by/year
Chimenti, M.S., Triggianese, P., Botti, E., Narcisi, A., Conigliaro, P., Giunta, A., et al. (2016). S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 44(1_suppl), 33-37 [10.1177/0300060515598900].
Chimenti, Ms; Triggianese, P; Botti, E; Narcisi, A; Conigliaro, P; Giunta, A; Teoli, M; Perricone, R; Costanzo, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/165603
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