We describe 70 children with myelodysplastic syndrome (MDS) (refractory cytopenia (n=31) and refractory anemia with excess blasts (n=30) or blasts in transformation (n=9)) who received umbilical cord blood (UCB) transplantation with a single UCB unit and a myeloablative conditioning regimen. Approximately 20% of children had secondary MDS. Median age at transplantation was 7 years and the median follow-up was 3 years. The day-60 probability of neutrophil recovery was 76%; recovery was faster after transplantation of matched or 1-locus mismatched UCB, irradiation-containing conditioning regimen, cell dose >6 × 10(7)/kg and monosomy 7. Risks of treatment failure (recurrent disease or death) were lower in patients with monosomy 7 and transplantations after 2001. The 3-year disease-free survival (DFS) was 50% for transplantations after 2001 compared with 27% for the earlier period (P=0.018). Transplantations after 2001 occurred within 6 months after diagnosis and used UCB units with higher cell dose. DFS was highest in patients with monosomy 7 (61%) compared with other karyotypes (30%), P=0.017. These data suggest that transplantation of mismatched UCB graft is an acceptable alternative for children without a matched sibling or suitably matched unrelated adult donor.
MADUREIRA AB, EAPEN M, LOCATELLI F, TEIRA P, ZHANG MJ, DAVIES SM, et al. (2011). Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation. LEUKEMIA, 25(3), 449-454.
|Tipologia:||Articolo su rivista|
|Citazione:||MADUREIRA AB, EAPEN M, LOCATELLI F, TEIRA P, ZHANG MJ, DAVIES SM, et al. (2011). Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation. LEUKEMIA, 25(3), 449-454.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
Settore MED/05 - Patologia Clinica
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/leu.2010.285|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2011|
|Titolo:||Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation|
|Autori:||Madureira, A; Eapen, M; Locatelli, F; Teira, P; Zhang, M; Davies, S; Picardi, A; Woolfrey, A; Chan, K; Socié, G; Vora, A; Bertrand, Y; SALES BONFIM CM, ; Gluckman, E; Niemeyer, C; Rocha, V|
|Appare nelle tipologie:||01 - Articolo su rivista|