Whether information from clinical trial registries (CTRs) and published randomised controlled trial (RCTs) differs remains unknown. Knowing more about discrepancies should alert those who rely on RCTs for medical decision-making to possible dissemination or reporting bias. To provide help in critically appraising research relevant for clinical practice we sought possible discrepancies between what CTRs record and paediatric RCTs actually publish. For this purpose, after identifying six reporting domains including funding, design, and outcomes, we collected data from 20 consecutive RCTs published in a widely read peer-reviewed paediatric journal and cross-checked reported features with those in the corresponding CTRs.

Rosati, P., Porzsolt, F., Ricciotti, G., Testa, G., Inglese, R., Giustini, F., et al. (2016). Major discrepancies between what clinical trial registries record and paediatric randomised controlled trials publish. TRIALS, 17(1), 430 [10.1186/s13063-016-1551-6].

Major discrepancies between what clinical trial registries record and paediatric randomised controlled trials publish

BALASSONE, VALERIO;FIORITO, ROBERTO;
2016

Abstract

Whether information from clinical trial registries (CTRs) and published randomised controlled trial (RCTs) differs remains unknown. Knowing more about discrepancies should alert those who rely on RCTs for medical decision-making to possible dissemination or reporting bias. To provide help in critically appraising research relevant for clinical practice we sought possible discrepancies between what CTRs record and paediatric RCTs actually publish. For this purpose, after identifying six reporting domains including funding, design, and outcomes, we collected data from 20 consecutive RCTs published in a widely read peer-reviewed paediatric journal and cross-checked reported features with those in the corresponding CTRs.
Pubblicato
Rilevanza internazionale
Articolo
Comitato scientifico
Settore MED/18 - Chirurgia Generale
Settore MED/20 - Chirurgia Pediatrica e Infantile
Settore MED/38 - Pediatria Generale e Specialistica
English
Con Impact Factor ISI
Clinical trial registries; Critical appraisal; Dissemination bias; Quality reporting; Randomised controlled trials; Reporting bias; Reporting discrepancies; Risk of bias; Selective outcome reporting
Rosati, P., Porzsolt, F., Ricciotti, G., Testa, G., Inglese, R., Giustini, F., et al. (2016). Major discrepancies between what clinical trial registries record and paediatric randomised controlled trials publish. TRIALS, 17(1), 430 [10.1186/s13063-016-1551-6].
Rosati, P; Porzsolt, F; Ricciotti, G; Testa, G; Inglese, R; Giustini, F; Fiscarelli, E; Zazza, M; Carlino, C; Balassone, V; Fiorito, R; D'Amico, R
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/164411
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