We recently described a protective effect of the low molecular weight protein tyrosine phosphatase (LMPTP) BC genotype, associated with the highest total enzymatic activity, against high serum IgE levels both in the English and the Italian populations. Here we test the hypothesis of a role of LMPTP in the negative modulation of IL-4 signal transduction checking for genetic interaction between interleukin-4 receptor alpha chain (IL-4RA) genetic polymorphisms and LMPTP polymorphism in the predisposition to high total IgE levels in the English population. We find a significant interaction between LMPTP polymorphism and the intracellular Gln/Arg polymorphism in position 551 of IL-4RA. Our data support the hypothesis of a direct or indirect biochemical interaction between LMPTP and IL-4RA resulting in different modulation of IL-4 signal transduction among joint genotypes.

Bottini, N., Mao, X., Borgiani, P., Saccucci, P., Stefanini, L., Greco, E., et al. (2002). Low molecular weight PTP-IL-4RA interaction in atopy predisposition. ALLERGY, 57 Suppl 72, 10-12.

Low molecular weight PTP-IL-4RA interaction in atopy predisposition

BOTTINI, NUNZIO;BORGIANI, PAOLA;SACCUCCI, PATRIZIA;GRECO, ELISABETTA;FONTANA, LUIGI;
2002

Abstract

We recently described a protective effect of the low molecular weight protein tyrosine phosphatase (LMPTP) BC genotype, associated with the highest total enzymatic activity, against high serum IgE levels both in the English and the Italian populations. Here we test the hypothesis of a role of LMPTP in the negative modulation of IL-4 signal transduction checking for genetic interaction between interleukin-4 receptor alpha chain (IL-4RA) genetic polymorphisms and LMPTP polymorphism in the predisposition to high total IgE levels in the English population. We find a significant interaction between LMPTP polymorphism and the intracellular Gln/Arg polymorphism in position 551 of IL-4RA. Our data support the hypothesis of a direct or indirect biochemical interaction between LMPTP and IL-4RA resulting in different modulation of IL-4 signal transduction among joint genotypes.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/01 - Statistica Medica
English
Con Impact Factor ISI
Isoenzymes; Protein Tyrosine Phosphatases; Immunoglobulin E; Asthma; Polymorphism, Restriction Fragment Length; Humans; Hypersensitivity, Immediate; Polymorphism, Genetic; Signal Transduction; Proto-Oncogene Proteins; Polymerase Chain Reaction; Receptors, Interleukin-4; Genetic Predisposition to Disease
Bottini, N., Mao, X., Borgiani, P., Saccucci, P., Stefanini, L., Greco, E., et al. (2002). Low molecular weight PTP-IL-4RA interaction in atopy predisposition. ALLERGY, 57 Suppl 72, 10-12.
Bottini, N; Mao, X; Borgiani, P; Saccucci, P; Stefanini, L; Greco, E; Fontana, L; Shirakawa, T; Hopkin, J
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/16408
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