Nowadays, there is a considerable gap in knowledge concerning the mechanism(s) by which long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) interact to induce bronchodilation. This study aimed to characterise the pharmacological interaction between glycopyrronium bromide and indacaterol fumarate and to identify the mechanism(s) leading to the bronchorelaxant effect of this interaction.

Cazzola, M., Calzetta, L., Puxeddu, E., Ora, J., Facciolo, F., Rogliani, P., et al. (2016). Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells. RESPIRATORY RESEARCH, 17(1) [10.1186/s12931-016-0386-8].

Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells

CAZZOLA, MARIO;PUXEDDU, ERMANNO;ROGLIANI, PAOLA;
2016

Abstract

Nowadays, there is a considerable gap in knowledge concerning the mechanism(s) by which long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) interact to induce bronchodilation. This study aimed to characterise the pharmacological interaction between glycopyrronium bromide and indacaterol fumarate and to identify the mechanism(s) leading to the bronchorelaxant effect of this interaction.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/10 - Malattie dell'Apparato Respiratorio
English
Glycopyrronium bromide; Human bronchi; Indacaterol fumarate; Synergistic interaction
Cazzola, M., Calzetta, L., Puxeddu, E., Ora, J., Facciolo, F., Rogliani, P., et al. (2016). Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells. RESPIRATORY RESEARCH, 17(1) [10.1186/s12931-016-0386-8].
Cazzola, M; Calzetta, L; Puxeddu, E; Ora, J; Facciolo, F; Rogliani, P; Matera, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/164071
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