To date there is emerging clinical evidence to add long-acting anti-muscarinic agents (LAMAs) with inhaled corticosteroid (ICSs) in asthma, but the pharmacological rationale that supports the use of such a combination has not yet been explained. The aim of this study was to pharmacologically investigate the interaction between the ICS beclomethasone and the LAMA glycopyrronium on the human airway smooth muscle (ASM) tone.

Cazzola, M., Calzetta, L., Rogliani, P., Puxeddu, E., Facciolo, F., & Matera, M. (2016). Interaction between corticosteroids and muscarinic antagonists in human airways. PULMONARY PHARMACOLOGY & THERAPEUTICS, 36, 1-9 [10.1016/j.pupt.2015.11.004].

Interaction between corticosteroids and muscarinic antagonists in human airways

CAZZOLA, MARIO;ROGLIANI, PAOLA;PUXEDDU, ERMANNO;
2016

Abstract

To date there is emerging clinical evidence to add long-acting anti-muscarinic agents (LAMAs) with inhaled corticosteroid (ICSs) in asthma, but the pharmacological rationale that supports the use of such a combination has not yet been explained. The aim of this study was to pharmacologically investigate the interaction between the ICS beclomethasone and the LAMA glycopyrronium on the human airway smooth muscle (ASM) tone.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/10 - Malattie dell'Apparato Respiratorio
English
Con Impact Factor ISI
Airway smooth muscle; Asthma; Drug interaction; ICS; LAMA; Aged; Anti-Inflammatory Agents; Beclomethasone; Bronchi; Bronchioles; Bronchodilator Agents; Cyclic AMP; Drug Interactions; Female; Glycopyrrolate; Histamine; Humans; In Vitro Techniques; Male; Middle Aged; Muscarinic Antagonists; Muscle Relaxation; Muscle Tonus; Muscle, Smooth; Respiratory Mucosa; Respiratory System; Signal Transduction
Cazzola, M., Calzetta, L., Rogliani, P., Puxeddu, E., Facciolo, F., & Matera, M. (2016). Interaction between corticosteroids and muscarinic antagonists in human airways. PULMONARY PHARMACOLOGY & THERAPEUTICS, 36, 1-9 [10.1016/j.pupt.2015.11.004].
Cazzola, M; Calzetta, L; Rogliani, P; Puxeddu, E; Facciolo, F; Matera, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/164051
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