Recent investigations suggest that Adenosine Deaminase (ADA) could play a role in susceptibility to rheumatoid arthritis (RA). The purpose of our study is to investigate the possible role of genetic variability of ADA in the susceptibility to RA. We studied three intragenic ADA polymorphisms, ADA1, ADA2 and ADA6, in a sample of 91 subjects with RA and in 246 healthy subjects from the same Caucasian population and compared genotype and pairwise haplotype distributions between cases and controls. No statistically significant differences between RA and controls are observed for ADA genotypes. A border line difference for ADA1-ADA2 haplotype distribution is observed due to a decreased proportion of ADA1 *2/ADA2 *2 haplotype in RA compared to controls. Our data indicate a border line effect of ADA gene polymorphism on susceptibility to RA that need to be confirmed in other clinical settings.

Sebastiani, G., Bottini, N., Greco, E., Saccucci, P., Canu, G., Lucarelli, P., et al. (2010). A study of Adenosine-Deaminase genetic polymorphism in rheumatoid arthritis. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 23(3), 791-795.

A study of Adenosine-Deaminase genetic polymorphism in rheumatoid arthritis

GRECO, ELISABETTA;SACCUCCI, PATRIZIA;CANU, GIOVANNA;GLORIA, FULVIA;FONTANA, LUIGI
2010-09-23

Abstract

Recent investigations suggest that Adenosine Deaminase (ADA) could play a role in susceptibility to rheumatoid arthritis (RA). The purpose of our study is to investigate the possible role of genetic variability of ADA in the susceptibility to RA. We studied three intragenic ADA polymorphisms, ADA1, ADA2 and ADA6, in a sample of 91 subjects with RA and in 246 healthy subjects from the same Caucasian population and compared genotype and pairwise haplotype distributions between cases and controls. No statistically significant differences between RA and controls are observed for ADA genotypes. A border line difference for ADA1-ADA2 haplotype distribution is observed due to a decreased proportion of ADA1 *2/ADA2 *2 haplotype in RA compared to controls. Our data indicate a border line effect of ADA gene polymorphism on susceptibility to RA that need to be confirmed in other clinical settings.
23-set-2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/01 - STATISTICA MEDICA
English
Codon; Male; Alleles; Rome; Middle Aged; DNA; Amino Acid Substitution; Female; Genotype; Adenosine Deaminase; Humans; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; DNA Primers; Haplotypes; Arthritis, Rheumatoid; Exons
Sebastiani, G., Bottini, N., Greco, E., Saccucci, P., Canu, G., Lucarelli, P., et al. (2010). A study of Adenosine-Deaminase genetic polymorphism in rheumatoid arthritis. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 23(3), 791-795.
Sebastiani, G; Bottini, N; Greco, E; Saccucci, P; Canu, G; Lucarelli, P; Gloria, F; Fontana, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/16341
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