Glaucoma is a disease where retinal ganglion cells (RGC) are specifically affected though a number of evidences endorse the hypothesis that glaucoma is a neuro-degenerative disorder of the central nervous system and suggest a possible connection between glaucomatous damage and cerebrovascular alterations. The mechanisms underlying RGC loss are not yet fully known but alterations of the autophagy machinery have been recently proposed as a potential contributing factor as for Alzheimer's disease. Here we review the current literature on new strategies for neuroprotection in glaucoma, focusing on pharmacologic strategies to minimize RGC damage.

Nucci, C., Russo, R., Martucci, A., Giannini, C., Garaci, F., Floris, R., et al. (2016). New strategies for neuroprotection in glaucoma,a disease that affects the central nervous system. EUROPEAN JOURNAL OF PHARMACOLOGY, 787, 119-126 [10.1016/j.ejphar.2016.04.030].

New strategies for neuroprotection in glaucoma,a disease that affects the central nervous system

NUCCI, CARLO;GARACI, FRANCESCO;FLORIS, ROBERTO;
2016-01-01

Abstract

Glaucoma is a disease where retinal ganglion cells (RGC) are specifically affected though a number of evidences endorse the hypothesis that glaucoma is a neuro-degenerative disorder of the central nervous system and suggest a possible connection between glaucomatous damage and cerebrovascular alterations. The mechanisms underlying RGC loss are not yet fully known but alterations of the autophagy machinery have been recently proposed as a potential contributing factor as for Alzheimer's disease. Here we review the current literature on new strategies for neuroprotection in glaucoma, focusing on pharmacologic strategies to minimize RGC damage.
2016
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/30 - MALATTIE APPARATO VISIVO
Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA
English
Con Impact Factor ISI
Glaucoma; Intraocular pressure; Neuroprotection; Optic nerve; Retinal ganglion cell
Nucci, C., Russo, R., Martucci, A., Giannini, C., Garaci, F., Floris, R., et al. (2016). New strategies for neuroprotection in glaucoma,a disease that affects the central nervous system. EUROPEAN JOURNAL OF PHARMACOLOGY, 787, 119-126 [10.1016/j.ejphar.2016.04.030].
Nucci, C; Russo, R; Martucci, A; Giannini, C; Garaci, F; Floris, R; Bagetta, G; Morrone, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/163117
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