Elevated levels of glutathione (GSH) have been reported to play an important role in mediating chemoresistance in tumor cells. The regulation of gamma-glutamylcysteine synthetase (gamma-GCS) is one of the major determinants of GSH homeostasis. The aim of our study was to investigate gamma-GCS gene expression in patients affected by acute myeloid leukemia (AML).

Carnicer, M.j., Bernardini, S., Bellincampi, L., Noguera, N.I., Nuccetelli, M., Ammatuna, E., et al. (2006). Role of γ-glutamyl cysteine synthetase (γ-GCS) gene expression as marker of drug sensitivity in acute myeloid leukemias. CLINICA CHIMICA ACTA, 365(1-2), 342-345 [10.1016/j.cca.2005.09.012].

Role of γ-glutamyl cysteine synthetase (γ-GCS) gene expression as marker of drug sensitivity in acute myeloid leukemias

Bernardini, S;NOGUERA, NELIDA INES;LO COCO, FRANCESCO;FEDERICI, GIORGIO
2006

Abstract

Elevated levels of glutathione (GSH) have been reported to play an important role in mediating chemoresistance in tumor cells. The regulation of gamma-glutamylcysteine synthetase (gamma-GCS) is one of the major determinants of GSH homeostasis. The aim of our study was to investigate gamma-GCS gene expression in patients affected by acute myeloid leukemia (AML).
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - Malattie del Sangue
English
Acute Disease; Antineoplastic Agents; Glutamate-Cysteine Ligase; Humans; Leukemia, Myeloid; RNA, Messenger; Reverse Transcriptase Polymerase Chain Reaction; Gene Expression
Carnicer, M.j., Bernardini, S., Bellincampi, L., Noguera, N.I., Nuccetelli, M., Ammatuna, E., et al. (2006). Role of γ-glutamyl cysteine synthetase (γ-GCS) gene expression as marker of drug sensitivity in acute myeloid leukemias. CLINICA CHIMICA ACTA, 365(1-2), 342-345 [10.1016/j.cca.2005.09.012].
Carnicer, M; Bernardini, S; Bellincampi, L; Noguera, Ni; Nuccetelli, M; Ammatuna, E; Breccia, M; LO COCO, F; Federici, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/162127
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